Schmitz Gerd, Orsó Evelyn
Institute for Clinical Chemistry and Laboratory medicine, University of Regensburg, Franz-Josef-Strauss-Allee 11, D-93053 Regensburg, Germany.
Curr Opin Lipidol. 2002 Oct;13(5):513-21. doi: 10.1097/00041433-200210000-00007.
Lipid rafts on monocytes/macrophages provide a dynamic microenvironment for an integrated lipopolysaccharide receptor (CD14)-dependent clustering of a set of receptors involved in innate immunity and clearance of atherogenic lipoproteins. The purpose of this review is to summarize the recent advances in our understanding of CD14-dependent receptor clustering and its relevance in atherogenesis.
Upon binding of various ligands, CD14 as a multiligand pattern recognition receptor induces specific coassembly of additional receptors present on circulating monocytes.
The composition of the receptor cluster and thus the associated signalling pathways defines a ligand specific cellular response, linking endogenous and exogenous host defense to a common recognition platform in rafts.
单核细胞/巨噬细胞上的脂筏为一组参与天然免疫和清除致动脉粥样硬化脂蛋白的受体提供了一个动态微环境，这些受体通过整合脂多糖受体（CD14）进行聚集。本综述旨在总结我们对CD14依赖性受体聚集及其在动脉粥样硬化发生过程中的相关性的最新认识进展。
作为多配体模式识别受体，CD14在与各种配体结合后，可诱导循环单核细胞上存在的其他受体发生特异性共组装。
受体簇的组成以及相关的信号通路决定了配体特异性细胞反应，将内源性和外源性宿主防御联系到脂筏中的一个共同识别平台。
