Zubova S V, Kosyakova N I, Grachev S V, Prokhorenko I R
Institute of Basic Biological Problems of RAS FRC PSCBR RAS, Pushchino, 142290 Russia.
Clinical Hospital at the Pushchino Research Center, Pushchino, 142290 Russia.
Acta Naturae. 2022 Oct-Dec;14(4):69-74. doi: 10.32607/actanaturae.11747.
Lipopolysaccharides (LPS) and lipoteichoic acids (LTA) are the major inducers of the inflammatory response of blood cells caused by Gram-negative and some Gram-positive bacteria. CD14 is a common receptor for LPS and LTA that transfers the ligands to TLR4 and TLR2, respectively. In this work, we have demonstrated that the non-toxic LPS from Rhodobacter capsulatus PG blocks the synthesis of pro-inflammatory cytokines during the activation of blood cells by Streptococcus pyogenes LTA through binding to the CD14 receptor, resulting in the signal transduction to TLR2/TLR6 being blocked. The LPS from Rhodobacter capsulatus PG can be considered a prototype for developing preparations to protect blood cells against the LTA of gram-positive bacteria.
脂多糖（LPS）和脂磷壁酸（LTA）是革兰氏阴性菌和一些革兰氏阳性菌引起血细胞炎症反应的主要诱导剂。CD14是LPS和LTA的共同受体，分别将配体传递给TLR4和TLR2。在这项工作中，我们已经证明，来自荚膜红细菌PG的无毒LPS通过与CD14受体结合，在化脓性链球菌LTA激活血细胞的过程中阻断促炎细胞因子的合成，导致向TLR2/TLR6的信号转导被阻断。来自荚膜红细菌PG的LPS可被视为开发保护血细胞免受革兰氏阳性菌LTA侵害的制剂的原型。
