Glance Laurent G, Osler Turner M, Dick Andrew
Department of Anaesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Crit Care Med. 2002 Sep;30(9):1976-82. doi: 10.1097/00003246-200209000-00005.
Intensive care units (ICUs) use severity-adjusted mortality measures such as the standardized mortality ratio to benchmark their performance. Prognostic scoring systems such as Acute Physiology and Chronic Health Evaluation (APACHE) II, Simplified Acute Physiology Score II, and Mortality Probability Model II0 permit performance-based comparisons of ICUs by adjusting for severity of disease and case mix. Whether different risk-adjustment methods agree on the identity of ICU quality outliers within a single database has not been previously investigated. The objective of this study was to determine whether the identity of ICU quality outliers depends on the ICU scoring system used to calculate the standardized mortality ratio.
DESIGN, SETTING, PATIENTS: Retrospective cohort study of 16,604 patients from 32 hospitals based on the outcomes database (Project IMPACT) created by the Society of Critical Care Medicine. The ICUs were a mixture of medical, surgical, and mixed medical-surgical ICUs in urban and nonurban settings. Standardized mortality ratios for each ICU were calculated using APACHE II, Simplified Acute Physiology Score II, and Mortality Probability Model II. ICU quality outliers were defined as ICUs whose standardized mortality ratio was statistically different from 1. Kappa analysis was used to determine the extent of agreement between the scoring systems on the identity of hospital quality outliers. The intraclass correlation coefficient was calculated to estimate the reliability of standardized mortality ratios obtained using the three risk-adjustment methods.
Kappa analysis showed fair to moderate agreement among the three scoring systems in identifying ICU quality outliers; the intraclass correlation coefficient suggested moderate to substantial agreement between the scoring systems. The majority of ICUs were classified as high-performance ICUs by all three scoring systems. All three scoring systems exhibited good discrimination and poor calibration in this data set.
APACHE II, Simplified Acute Physiology Score II, and Mortality Probability Model II0 exhibit fair to moderate agreement in identifying quality outliers. However, the finding that most ICUs in this database were judged to be high-performing units limits the usefulness of these models in their present form for benchmarking.
重症监护病房(ICU)使用标准化死亡率等经过病情严重程度调整的死亡率指标来衡量其绩效。急性生理学与慢性健康状况评估(APACHE)II、简化急性生理学评分II和死亡概率模型II等预后评分系统,通过对疾病严重程度和病例组合进行调整,允许对ICU进行基于绩效的比较。此前尚未研究过不同的风险调整方法在单个数据库中对ICU质量异常值的识别是否一致。本研究的目的是确定ICU质量异常值的识别是否取决于用于计算标准化死亡率的ICU评分系统。
设计、设置、患者:基于危重病医学会创建的结局数据库(影响项目),对来自32家医院的16604例患者进行回顾性队列研究。这些ICU包括城市和非城市环境中的内科、外科以及内外混合的ICU。使用APACHE II、简化急性生理学评分II和死亡概率模型II计算每个ICU的标准化死亡率。ICU质量异常值定义为标准化死亡率与1有统计学差异的ICU。使用kappa分析来确定评分系统在医院质量异常值识别上的一致程度。计算组内相关系数以估计使用三种风险调整方法获得的标准化死亡率的可靠性。
kappa分析显示,三种评分系统在识别ICU质量异常值方面的一致性为中等;组内相关系数表明评分系统之间的一致性为中等至高度。大多数ICU在所有三种评分系统中都被归类为高性能ICU。在该数据集中,所有三种评分系统均表现出良好的区分度和较差的校准度。
APACHE II、简化急性生理学评分II和死亡概率模型II在识别质量异常值方面表现出中等程度的一致性。然而,该数据库中大多数ICU被判定为高性能单位这一发现限制了这些模型目前形式在基准比较中的实用性。