Horányi M, Sárfy H
Acta Med Acad Sci Hung. 1975;32(2):123-7.
Oral ingestion of powdered duodenal mucosa with small doses of vitamin B12 proved efficient in four cases of untreated pernicious anaemia. The erythropoietic as well as the other responses were similar as those elicited by any reliable anti-pernicious drug. It has thus been confirmed that the growth factor demonstrated earlier in human duodenal juice by means of E. coli mutant corresponds in fact to the intrinsic factor. It is suggested that besides the deficiency of gastric intrinsic factor the duodenal intrinsic factor and the immune mechanisms neutralizing it are also involved in the pathogenesis. It has been shown that the aqueous extracts of hog stomach and duodenum differ in addition to their growth factor and nitrogen contents, also in aminoacid composition.
口服小剂量维生素B12的十二指肠黏膜粉末对4例未经治疗的恶性贫血患者有效。红细胞生成反应以及其他反应与任何可靠的抗恶性贫血药物所引发的反应相似。由此证实，此前通过大肠杆菌突变体在人十二指肠液中发现的生长因子实际上就是内因子。有人提出，除了胃内因子缺乏外，十二指肠内因子及其免疫中和机制也参与了发病过程。研究表明，猪胃和十二指肠的水提取物除了生长因子和氮含量不同外，氨基酸组成也不同。
