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十二指肠内因子对标记维生素B12吸收的影响。

Influence of duodenal intrinsic factor on the absorption of labelled vitamin B12.

作者信息

Horányi M, Gasztonyi G, Sárfy E

出版信息

Acta Med Acad Sci Hung. 1978;35(1):61-6.

PMID:735713
Abstract

The intrinsic factor activity of powdered hog duodenal mucosa was confirmed by measurements of the absorption of labelled vitamin B 12 (Schilling-test) in 7 cases of Addisonian pernicious anaemia. In view of the fact that, according to earlier studies of the authors based on a bacteriological test, human duodenal juice also exhibits an intrinsic factor activity, it is suggested that the duodenal intrinsic factor may be involved in the pathogenesis of pernicious anaemia. The results of the Schilling-test are critically reviewed in the light of recent published evidence.

摘要

通过对7例阿狄森恶性贫血患者进行标记维生素B12吸收测定(希林试验),证实了猪十二指肠黏膜粉的内因子活性。鉴于作者早期基于细菌学试验的研究表明,人十二指肠液也具有内因子活性,提示十二指肠内因子可能参与恶性贫血的发病机制。根据最近发表的证据,对希林试验的结果进行了严格审查。

相似文献

1
Influence of duodenal intrinsic factor on the absorption of labelled vitamin B12.十二指肠内因子对标记维生素B12吸收的影响。
Acta Med Acad Sci Hung. 1978;35(1):61-6.
2
[The effect of duodenal intrinsic factor on the absorption of radio isotope labeled vitamin B-12].
Orv Hetil. 1978 Apr 30;119(18):1083-7.
3
Pernicious anaemia: its pathogenesis in the light of the beneficial effect of duodenal intrinsic factor.恶性贫血:鉴于十二指肠内因子的有益作用探讨其发病机制
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Patterns of vitamin B 12 absorption in humans mediated by homologous and heterologous intrinsic factors.
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5
Intestinal absorption of vitamin B12 in patients with chronic pancreatic insufficiency and the effect of human duodenal juice on the intestinal uptake of vitamin B12.慢性胰腺功能不全患者维生素B12的肠道吸收及人十二指肠液对维生素B12肠道摄取的影响
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Evidence that pancreatic proteases enhance vitamin B12 absorption by acting on curde preparations of hog gastric intrinsic factor and human gastric juice.有证据表明,胰腺蛋白酶通过作用于猪胃内因子粗制品和人胃液来增强维生素B12的吸收。
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7
[Transient malabsorption of Vitamin B12 bound to intrinsic factor in pernicious anemia (author's transl)].恶性贫血中与内因子结合的维生素B12的短暂吸收不良(作者译)
Nouv Rev Fr Hematol. 1975 Jan-Feb;15(1):107-18.
8
Schilling evaluation of pernicious anemia: current status.恶性贫血的希林试验评估:现状
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Intrinsic-factor antibody and absorption of vtiamin B12 in pernicious anaemia.内因子抗体与恶性贫血中维生素B₁₂的吸收
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