Elmore James M, Baker Linda A, Snodgrass Warren T
Department of Urology, Children's Medical Center and The University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
J Urol. 2002 Oct;168(4 Pt 2):1746-7; discussion 1747. doi: 10.1097/01.ju.0000027260.18990.9b.
PURPOSE Topical steroids are an effective alternative to circumcision for the treatment of phimosis. However, their use has been reported primarily in older boys thought to have "pathological" or secondary phimosis. We report the effectiveness of topical steroids as an alternative to circumcision in infants and young children.
We evaluated 27 boys with phimosis for possible circumcision because of genitourinary anomalies (4), a history of urinary tract infection (11) or both (7), or balanoposthitis (5). Patient age ranged from 1 to 31 months (mean 11.3). In no case could the prepuce be retracted to visualize the meatus. Patients were treated with 0.05% betamethasone cream applied to the distal aspect of the prepuce twice daily for 1 month.
Of the boys 20 (74%) had fully retractable foreskins after 1 month of treatment with betamethasone and 5 (18%) had a partial response at 1 month, with the prepuce becoming fully retractable during month 2 of therapy. No adverse side effects were noted. Of the 2 patients in whom treatment failed 1 subsequently underwent circumcision while the parents of the other refused further therapy.
Topical steroids appear to resolve phimosis effectively in boys younger than 3 years. Given proven efficacy in children older than 3 years, topical steroid therapy represents a potential alternative to circumcision regardless of the age of the patient, type of phimosis or relative indication for treatment.
目的 局部用类固醇是治疗包茎的一种有效替代包皮环切术的方法。然而,其使用主要报道于被认为患有“病理性”或继发性包茎的大龄男孩。我们报告局部用类固醇作为婴儿和幼儿包皮环切术替代方法的有效性。
我们评估了27例因泌尿生殖系统异常(4例)、有尿路感染史(11例)或两者皆有(7例)或阴茎头包皮炎(5例)而可能需要行包皮环切术的包茎男孩。患者年龄为1至31个月(平均11.3个月)。在任何情况下包皮均无法上翻以显露尿道口。患者每日两次在包皮远端涂抹0.05%倍他米松乳膏,持续1个月。
在这些男孩中,20例(74%)在使用倍他米松治疗1个月后包皮可完全上翻,5例(18%)在1个月时有部分反应,包皮在治疗的第2个月时完全可上翻。未观察到不良副作用。在2例治疗失败的患者中,1例随后接受了包皮环切术,而另1例患者的父母拒绝进一步治疗。
局部用类固醇似乎能有效解决3岁以下男孩的包茎问题。鉴于已证实其在3岁以上儿童中的疗效,无论患者年龄、包茎类型或相对治疗指征如何,局部用类固醇疗法是包皮环切术的一种潜在替代方法。