Schroeter Matthias L, Abdul-Khaliq Hashim, Diefenbacher Albert, Blasig Ingolf E
Queen Elisabeth Hospital, Department of Psychiatry, 10362 Berlin, Germany.
Neuroreport. 2002 Sep 16;13(13):1675-8. doi: 10.1097/00001756-200209160-00021.
Previous studies have reported alterations of glial cells and particularly astrocytes in mood disorders. Therefore, serum concentration of the astrocytic marker S100B was ascertained with an immunoluminometric assay in 20 patients with mood disorder and 12 healthy age-matched controls. Serum S100B was elevated in major depression (median after admission 410 ng/l, at discharge < 100 ng/l) and mania (130, 160 ng/l), when compared with controls (< 100 ng/l; rho< 0.01). Antidepressive treatment reduced S100B in conjunction with severity of depressive symptoms ( rho< 0.01). The severity of depression (Hamilton Depression Rating Scale) was positively correlated with S100B (r(s) = 0.51, rho< 0.005). Elevated serum S100B during depressive and manic episodes of mood disorders may indicate alterations of astrocytes, which are reversed by antidepressive treatment.
以往研究报道了情绪障碍中胶质细胞尤其是星形胶质细胞的改变。因此，采用免疫发光分析法测定了20例情绪障碍患者和12例年龄匹配的健康对照者血清中星形胶质细胞标志物S100B的浓度。与对照组（<100 ng/l；rho<0.01）相比，重度抑郁（入院后中位数410 ng/l，出院时<100 ng/l）和躁狂症（130、160 ng/l）患者血清S100B升高。抗抑郁治疗使S100B降低，且与抑郁症状严重程度相关（rho<0.01）。抑郁严重程度（汉密尔顿抑郁量表）与S100B呈正相关（r(s)=0.51，rho<0.005）。情绪障碍抑郁和躁狂发作期间血清S100B升高可能表明星形胶质细胞发生改变，而抗抑郁治疗可使其逆转。
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