对人及兔凝血活酶国际参考制剂之间关系的重新评估。
A reassessment of the relationship between international reference preparations for human and rabbit thromboplastins.
作者信息
van den Besselaar A M H P, Tripodi A
机构信息
Haemostasis and Thrombosis Research Centre, Leiden University Medical Centre, Leiden, The Netherlands.
出版信息
Thromb Haemost. 2002 Sep;88(3):459-61.
Two established international reference preparations (IRP) for thromboplastins, i.e. RBT/90 (rabbit, plain) and rTF/95 (recombinant human, plain) have been calibrated against each other in a 7-centre exercise performed in 2000. The purpose of the study was to compare the calibration results with those of the original calibration study performed in 1995. The international sensitivity index (ISI) for rTF/95 was calculated relative to the ISI for RBT/90. The mean ISI for rTF/95 was 0.961 (between-lab SD 0.028) which was 2% greater than the historical value determined in 1995. There is no indication that the two IRP have deteriorated, but further monitoring of the calibration relationship is recommended.
两种已确立的国际组织凝血活酶参考制剂（IRP），即RBT/90（兔，普通型）和rTF/95（重组人，普通型），于2000年在一项7中心试验中相互进行了校准。该研究的目的是将校准结果与1995年进行的原始校准研究结果进行比较。相对于RBT/90的国际敏感度指数（ISI），计算出了rTF/95的ISI。rTF/95的平均ISI为0.961（实验室间标准差0.028），比1995年确定的历史值高2%。没有迹象表明这两种IRP已经变质，但建议对校准关系进行进一步监测。
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