The role of reproductive hormones in maintaining cognition.

This article briefly reviews the impact of hormones on cognition. Estrogen has the most profound impact on brain functioning. Testosterone also seems to have significant brain-related benefits, whereas progesterone seems to have minor or possibly even adverse effects. As the field of neuroscience progresses, more definitive conclusions will follow. As the focus is shifted, however, from extending life to improving the quality of life, the existing data are very compelling. The brain is a target for the sex steroid hormones. Clearly, this is an exciting and dynamic area for further study. Although skeptics may believe that more definitive proof is necessary before recommending hormone replacement for their patients to preserve their cognitive health, it seems prudent to discuss the evidence available to empower the patient further to guide their own treatment options and validate their symptoms. For those who still subscribe to the menopause-is-natural philosophy this question is posed, "why does the brain naturally have sex hormone receptors if they are not necessary?"