卵巢激素在维持衰老过程中认知功能方面的作用。
The role of ovarian hormones in preserving cognition in aging.
作者信息
Janowsky Jeri S
机构信息
Departments of Neurology and Behavioral Neuroscience, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97201, USA.
出版信息
Curr Psychiatry Rep. 2002 Dec;4(6):467-73. doi: 10.1007/s11920-002-0075-9.
Hormone replacement therapy is now the standard of care for amelioration of the symptoms of menopause and prevention of osteoporosis. More recently, it has been appreciated that hormone replacement may also have beneficial effects on the brain. This review will contrast the biologic data showing that estrogen has significant neuroprotectant effects on the brain, with data from cross-sectional and epidemiologic studies of women showing that hormone replacement may have beneficial effects for cognition in aging. Together, studies suggest that the temporal pattern of hormone replacement may be critical for maintaining cognitive health in aging.
激素替代疗法如今是改善更年期症状和预防骨质疏松症的标准治疗方法。最近，人们认识到激素替代疗法可能对大脑也有有益影响。本综述将对比显示雌激素对大脑具有显著神经保护作用的生物学数据，以及对女性进行的横断面研究和流行病学研究的数据，这些数据表明激素替代疗法可能对衰老过程中的认知有有益影响。综合来看，研究表明激素替代疗法的时间模式对于维持衰老过程中的认知健康可能至关重要。
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