García Ramos J, de la Cerda E, Ibarra B H, Orozco C
Acta Physiol Lat Am. 1975;25(6):433-45.
By using the mescaline or the strychnine spikes as indicators of electrocortical activity it was found that they are increased in size by some catecholamines topically applied. These spikes showed late and long-lasting changes after somatic, as well as after autonomic afferent stimulation. The latter induced by cyanide, light asphyxia, intravenous injections of adrenaline or noradrenaline, and after a small dose of 6-hydroxydopamine. After a dose of this last substance, high enough to deplete the catecholamines of the brain, the late increase in amplitude of the cortical potentials observed following afferent stimulation disappeared leaving a long lasting reduction in that amplitude. The hypothesis is presented that the noradrenaline liberated by the adrenergic nerve fibers reaching the upper layers of the cortex acts on the nonsynaptic dendritic membranes modulating their activity in a humoral-like way. The pattern of this facilitating effect has a different temporal course and is longer lasting than that which is to be expectec only by the arrival of impulses at the cortex during the persistence of the neuronal activation induced by the information input to the CNS.
通过使用麦司卡林或士的宁峰作为皮层电活动的指标，发现局部应用某些儿茶酚胺会使其大小增加。这些峰在躯体以及自主传入刺激后显示出晚期且持久的变化。后者由氰化物、轻度窒息、静脉注射肾上腺素或去甲肾上腺素以及小剂量的6-羟基多巴胺诱导。在给予最后一种物质的剂量足够高以耗尽大脑中的儿茶酚胺后，传入刺激后观察到的皮层电位振幅的晚期增加消失，留下该振幅的长期降低。提出的假说是，到达皮层上层的肾上腺素能神经纤维释放的去甲肾上腺素作用于非突触树突膜，以类似体液的方式调节其活动。这种促进作用的模式具有不同的时间进程，并且比仅由信息输入到中枢神经系统所诱导的神经元激活持续期间冲动到达皮层所预期的作用更持久。
