Patke Deepa S, Langan Susan J, Carruth Lucy M, Keating Sheila M, Sabundayo Beulah P, Margolick Joseph B, Quinn Thomas C, Bollinger Robert C
Division of Infectious Diseases, Johns Hopkins University School of Medicine, Ross 1150, 720 Rutland Avenue, Baltimore, MD 21205, USA.
J Infect Dis. 2002 Oct 15;186(8):1177-80. doi: 10.1086/343811. Epub 2002 Sep 30.
T lymphocyte responses to human immunodeficiency virus (HIV) type 1 Gag were measured in 9 patients by interferon-gamma enzyme-linked immunospot assay at 3 time points within 12 months of infection. Patients with early recognition of HIV-1 Gag had lower subsequent HIV-1 load set points, as measured during the first 2 years of infection, compared with those of patients with undetectable Gag-specific responses (median, 4.27 vs. 5.05 log(10) HIV-1 RNA copies/mL, respectively; P=.028). An inverse correlation existed between the magnitude of the Gag-specific responses and the HIV-1 load set point (r=-0.733; P=.025). Early sustained T lymphocyte responses to HIV-1 Gag may be important for the establishment of virus load set point.
通过干扰素-γ酶联免疫斑点试验，在感染后12个月内的3个时间点，对9名患者的T淋巴细胞对1型人类免疫缺陷病毒（HIV）Gag的反应进行了检测。与Gag特异性反应检测不到的患者相比，在感染的头2年中，早期识别HIV-1 Gag的患者随后的HIV-1载量设定点较低（中位数分别为4.27对5.05 log(10) HIV-1 RNA拷贝/mL；P = 0.028）。Gag特异性反应的强度与HIV-1载量设定点之间存在负相关（r = -0.733；P = 0.025）。早期持续的T淋巴细胞对HIV-1 Gag的反应可能对病毒载量设定点的建立很重要。
