人类免疫缺陷病毒感染儿童中记忆性Gag特异性细胞毒性T淋巴细胞与病毒复制之间的负相关。

Inverse correlation between memory Gag-specific cytotoxic T lymphocytes and viral replication in human immunodeficiency virus-infected children.

作者信息

Buseyne Florence, Le Chenadec Jérôme, Corre Béatrice, Porrot Françoise, Burgard Marianne, Rouzioux Christine, Blanche Stéphane, Mayaux Marie-Jeanne, Rivière Yves

机构信息

Laboratoire d'Immunopathologie Virale, Unité de Recherche Associée Centre National de la Recherche Scientifique 1930, Institut Pasteur, 75724 Paris Cedex 15, France.

出版信息

J Infect Dis. 2002 Dec 1;186(11):1589-96. doi: 10.1086/345482. Epub 2002 Nov 1.

DOI:10.1086/345482

PMID:12447734

Abstract

A previous study showed that, during the first year of life, the presence of cytotoxic T lymphocytes (CTLs) in human immunodeficiency virus (HIV)-infected children is associated with a lack of rapid progression to acquired immunodeficiency syndrome. The goal of the study was to address the role of CTLs in children who survived after age 5 years. Memory HIV-specific CTLs directed against Env, Gag, Nef, and Pol proteins were measured in a group of 47 highly active antiretroviral therapy-naive HIV-infected children. Both Gag- and Pol-specific CTLs were positively correlated with CD4(+) T cell counts. Gag-, Nef-, and Pol-specific CTLs were inversely correlated with virus load. The inverse correlation between virus load and Gag-specific CTLs was independent of CD4(+) T cell counts. In conclusion, this study showed the beneficial role of HIV-specific CTLs in children who survived after age 5 years.

摘要

先前的一项研究表明，在生命的第一年，人类免疫缺陷病毒（HIV）感染儿童体内细胞毒性T淋巴细胞（CTL）的存在与未迅速发展为获得性免疫缺陷综合征有关。该研究的目的是探讨CTL在5岁后存活儿童中的作用。在一组47名未接受过高效抗逆转录病毒治疗的HIV感染儿童中，检测了针对Env、Gag、Nef和Pol蛋白的记忆性HIV特异性CTL。Gag特异性和Pol特异性CTL均与CD4(+) T细胞计数呈正相关。Gag特异性、Nef特异性和Pol特异性CTL与病毒载量呈负相关。病毒载量与Gag特异性CTL之间的负相关独立于CD4(+) T细胞计数。总之，本研究表明HIV特异性CTL在5岁后存活儿童中发挥了有益作用。