Tosh Kerrie, Meisner Sarah, Siddiqui M Ruby, Balakrishnan Karuppiah, Ghei Satish, Golding Marina, Sengupta Utpal, Pitchappan Ramasamy M, Hill Adrian V S
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
J Infect Dis. 2002 Oct 15;186(8):1190-3. doi: 10.1086/343806. Epub 2002 Sep 30.
A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p13) by genome-wide linkage analysis. Microsatellite markers from this genome screen that showed suggestive evidence of linkage to leprosy were evaluated in an additional 140 families with affected sib pairs. A second region of linkage has thus been identified on chromosome 20 (20p12). The peak of linkage lies at marker D20S115, which has a significant single-point maximum logarithm of odds score of 3.48 (P=.00003). Transmission disequilibrium testing of the microsatellite markers in 20p12 showed that the marker D20S835 is associated with protection against leprosy (P=.021), which suggests that a locus controlling susceptibility lies close to this marker.
最近通过全基因组连锁分析，在10号染色体（10p13）上定位了一个主要的麻风易感基因座。对该基因组筛选中显示出与麻风病有提示性连锁证据的微卫星标记，在另外140个有病患同胞对的家庭中进行了评估。因此，在20号染色体（20p12）上确定了第二个连锁区域。连锁峰值位于标记D20S115处，其单点最大对数优势分数为3.48（P = 0.00003），具有显著性。对20p12区域的微卫星标记进行传递不平衡检验表明，标记D20S835与预防麻风病相关（P = 0.021），这表明控制易感性的基因座靠近该标记。
