人类多态性作为麻风病的临床预测指标。
Human polymorphisms as clinical predictors in leprosy.
机构信息
Pharmaceutical and Medical Biotechnology Unit, Research Center in Technology and Design Assistance of Jalisco State, National Council of Science and Technology, 44270 Guadalajara, JAL, Mexico.
出版信息
J Trop Med. 2011;2011:923943. doi: 10.1155/2011/923943. Epub 2011 Dec 18.
Abstract
Genetic and serum markers in human host can predict leprosy susceptibility per se as well as be useful in classification and/or prediction of clinical variants and immunological responses in leprosy. Adequate and timely assessment of potential risks associated with these 38 host leprosy genes could diminish epidemiological burden and improve life quality of patients with this still prevalent mycobacterial disease.
摘要
人类宿主中的遗传和血清标志物本身可以预测麻风病易感性，并且有助于麻风病的分类和/或临床变异和免疫反应的预测。充分和及时评估与这 38 个宿主麻风病基因相关的潜在风险，可以减轻流行病学负担，提高这种仍然流行的分枝杆菌病患者的生活质量。
相似文献
1
Human polymorphisms as clinical predictors in leprosy.人类多态性作为麻风病的临床预测指标。
J Trop Med. 2011;2011:923943. doi: 10.1155/2011/923943. Epub 2011 Dec 18.
2
Genetics of host resistance and susceptibility to intramacrophage pathogens: a study of multicase families of tuberculosis, leprosy and leishmaniasis in north-eastern Brazil.宿主对巨噬细胞内病原体的抗性和易感性遗传学：对巴西东北部结核病、麻风病和利什曼病多病例家庭的研究。
Int J Parasitol. 1998 Jan;28(1):21-8. doi: 10.1016/s0020-7519(97)00175-6.
3
Association of Exon 1 Polymorphisms With Multibacillary Leprosy.外显子 1 多态性与多菌型麻风的关联。
Front Immunol. 2020 Sep 3;11:1927. doi: 10.3389/fimmu.2020.01927. eCollection 2020.
4
Polymorphisms in genes TLR1, 2 and 4 are associated with differential cytokine and chemokine serum production in patients with leprosy.基因TLR1、2和4中的多态性与麻风病患者血清中细胞因子和趋化因子的不同产生有关。
Mem Inst Oswaldo Cruz. 2017 Apr;112(4):260-268. doi: 10.1590/0074-02760160366. Epub 2017 Mar 2.
5
An RFLP map for 2q33-q37 from multicase mycobacterial and leishmanial disease families: no evidence for an Lsh/Ity/Bcg gene homologue influencing susceptibility to leprosy.来自多病例分枝杆菌病和利什曼病家族的2q33 - q37区域的限制性片段长度多态性图谱：无证据表明存在影响麻风易感性的Lsh/Ity/Bcg基因同源物。
Ann Hum Genet. 1993 Oct;57(4):251-71. doi: 10.1111/j.1469-1809.1993.tb00899.x.
6
Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states.NOD2 基因区域的常见多态性与麻风及其反应状态有关。
J Infect Dis. 2010 May 1;201(9):1422-35. doi: 10.1086/651559.
7
Immunogenetics of leishmanial and mycobacterial infections: the Belem Family Study.利什曼原虫和分枝杆菌感染的免疫遗传学：贝伦家族研究
Philos Trans R Soc Lond B Biol Sci. 1997 Sep 29;352(1359):1331-45. doi: 10.1098/rstb.1997.0118.
8
Leprosy pathogenetic background: a review and lessons from other mycobacterial diseases.麻风病的发病机制背景：综述及其他分枝杆菌病的经验教训
Arch Dermatol Res. 2009 Feb;301(2):123-37. doi: 10.1007/s00403-008-0917-3. Epub 2008 Nov 29.
9
Association of vitamin D receptor genotype with leprosy type.维生素D受体基因型与麻风病类型的关联。
J Infect Dis. 1999 Jan;179(1):187-91. doi: 10.1086/314536.
10
Leprosy susceptibility: genetic variations regulate innate and adaptive immunity, and disease outcome.麻风病易感性：遗传变异调节先天和适应性免疫以及疾病结局。
Future Microbiol. 2011 May;6(5):533-49. doi: 10.2217/fmb.11.39.
引用本文的文献
1
Interleukin-17A in Egyptian leprosy patients: a clinical, genetic, and biochemical study.埃及麻风病患者白细胞介素-17A：临床、遗传和生化研究。
An Bras Dermatol. 2022 Nov-Dec;97(6):735-741. doi: 10.1016/j.abd.2021.09.016. Epub 2022 Sep 21.
2
Molecular studies on ancient M. tuberculosis and M. leprae: methods of pathogen and host DNA analysis.古代结核分枝杆菌和麻风分枝杆菌的分子研究：病原体与宿主DNA分析方法
Eur J Clin Microbiol Infect Dis. 2015 Sep;34(9):1733-49. doi: 10.1007/s10096-015-2427-5. Epub 2015 Jul 26.
3
The +3187A/G HLA-G polymorphic site is associated with polar forms and reactive reaction in leprosy.HLA-G 基因+3187A/G 多态性位点与麻风病的两极形式和反应性反应有关。
Mol Genet Genomic Med. 2013 Sep;1(3):123-30. doi: 10.1002/mgg3.14. Epub 2013 Jun 7.
本文引用的文献
1
Human β-defensin 1 (DEFB1) allele and genotype frequencies probably impact on ethnic susceptibility to atopic dermatitis.
Int J Dermatol. 2013 Jan;52(1):115-7. doi: 10.1111/j.1365-4632.2010.04853.x.
2
TLR6-driven lipid droplets in Mycobacterium leprae-infected Schwann cells: immunoinflammatory platforms associated with bacterial persistence.分枝杆菌感染雪旺细胞中的 TLR6 驱动的脂滴：与细菌持续存在相关的免疫炎症平台。
J Immunol. 2011 Sep 1;187(5):2548-58. doi: 10.4049/jimmunol.1101344. Epub 2011 Aug 3.
3
Interleukin 4-590T/C polymorphism and susceptibility to leprosy.白细胞介素4 - 590T/C多态性与麻风病易感性
Genet Test Mol Biomarkers. 2011 Dec;15(12):877-81. doi: 10.1089/gtmb.2011.0032. Epub 2011 Jul 12.
4
Phenylbutyrate counteracts Shigella mediated downregulation of cathelicidin in rabbit lung and intestinal epithelia: a potential therapeutic strategy.苯丁酸酯可拮抗志贺氏菌介导的兔肺和肠上皮细胞 cathelicidin 的下调：一种潜在的治疗策略。
PLoS One. 2011;6(6):e20637. doi: 10.1371/journal.pone.0020637. Epub 2011 Jun 3.
5
Mannose-binding lectin serum levels in patients with leprosy are influenced by age and MBL2 genotypes.麻风病患者血清甘露糖结合凝集素水平受年龄和 MBL2 基因型影响。
Int J Infect Dis. 2011 Aug;15(8):e551-7. doi: 10.1016/j.ijid.2011.04.008. Epub 2011 Jun 2.
6
Genetics of infectious diseases: hidden etiologies and common pathways.传染病遗传学：隐匿病因与共同通路。
Clin Chem Lab Med. 2011 Sep;49(9):1427-37. doi: 10.1515/CCLM.2011.620. Epub 2011 May 27.
7
Leprosy susceptibility: genetic variations regulate innate and adaptive immunity, and disease outcome.麻风病易感性：遗传变异调节先天和适应性免疫以及疾病结局。
Future Microbiol. 2011 May;6(5):533-49. doi: 10.2217/fmb.11.39.
8
Human genetic susceptibility to intracellular pathogens.人体对细胞内病原体的遗传易感性。
Immunol Rev. 2011 Mar;240(1):105-16. doi: 10.1111/j.1600-065X.2010.00996.x.
9
Experimental leprosy: a model of epithelioid cell granuloma.实验性麻风：上皮样细胞肉芽肿模型。
Int J Dermatol. 2011 Mar;50(3):255-61. doi: 10.1111/j.1365-4632.2010.04805.x.
10
Leprosy and the human genome.麻风病与人类基因组。
Microbiol Mol Biol Rev. 2010 Dec;74(4):589-620. doi: 10.1128/MMBR.00025-10.
Zotero 插件