Villarreal Gerardo, Petropoulos Helen, Hamilton Derek A, Rowland Laura M, Horan William P, Griego Jacqueline A, Moreshead Margaret, Hart Blaine L, Brooks William M
PTSD Clinic, Veterans Administration Hospital, Departments of Psychiatry and Neurosciences, University of New Mexico, Albuquerque, New Mexico, USA.
Can J Psychiatry. 2002 Sep;47(7):666-70. doi: 10.1177/070674370204700709.
Previous proton magnetic resonance spectroscopy (1H-MRS) studies in posttraumatic stress disorder (PTSD) report decreased hippocampal N-acetylaspartate (NAA), an indicator of neuronal integrity. However, other areas of the brain need to be explored. The objective of this study was to investigate the specificity of hippocampal NAA concentration changes in PTSD by also examining a control region, the occipital white matter (OWM).
Eight patients with PTSD and 5 control subjects underwent single-voxel 1H-MRS of the hippocampi and bilateral OWM. Absolute neurometabolite concentrations were determined.
Trends toward reduced left hippocampal NAA and creatine (Cre) were found in the PTSD group. PTSD subjects also had reduced bilateral OWM Cre.
The preliminary results of our study in civilians with PTSD replicate previous MRS studies and are consistent with decreased hippocampal neuronal integrity without effects in the OWM. Replication of our findings is needed.
以往关于创伤后应激障碍（PTSD）的质子磁共振波谱（1H-MRS）研究报告称，海马体中神经元完整性指标N-乙酰天门冬氨酸（NAA）减少。然而，大脑的其他区域也需要进行探索。本研究的目的是通过同时检查一个对照区域——枕叶白质（OWM），来研究PTSD中海马体NAA浓度变化的特异性。
8例PTSD患者和5名对照受试者接受了海马体和双侧OWM的单体素1H-MRS检查。测定了神经代谢物的绝对浓度。
在PTSD组中发现左侧海马体NAA和肌酸（Cre）有降低趋势。PTSD受试者双侧OWM的Cre也降低。
我们对PTSD平民患者的研究初步结果重复了以往的MRS研究，与海马体神经元完整性降低一致，而对OWM无影响。需要重复我们的研究结果。
