Kamei Hiroshi, Nakajima Takashi, Fukuhara Nobuyoshi
National Saigata Hospital, 468-1 Saigata, Ogata, Nakakubiki, Niigata 949-3193, Japan.
No To Shinkei. 2002 Aug;54(8):667-72.
We studied regional cerebral blood flow (rCBF) in 16 patients with Parkinson's disease (PD), 2 patients with dementia with Lewy bodies (DLB), 2 patients with progressive supranuclear palsy (PSP), 2 patients with striatonigral degeneration, and 16 normal volunteers, using Three-dimensional stereotactic surface projections (3 D-SSP). Decreased rCBF in PD patients was shown in the posterior parietal and occipital cortex. Decreased rCBF in DLB was shown in the frontal, parietal and occipital cortex with relative sparing of the sensorimotor cortex. Decreased rCBF in PSP was shown in the frontal cortex. Decreased rCBF in SND was shown in the frontal cortex and cerebellum. Statistic rCBF analysis using 3 D-SSP was a useful measure for the early differential diagnosis of extrapyramidal disorders.
我们使用三维立体定向表面投影（3D - SSP）技术，对16例帕金森病（PD）患者、2例路易体痴呆（DLB）患者、2例进行性核上性麻痹（PSP）患者、2例纹状体黑质变性患者以及16名正常志愿者的局部脑血流量（rCBF）进行了研究。PD患者的rCBF在顶叶后部和枕叶皮质降低。DLB患者的rCBF在额叶、顶叶和枕叶皮质降低，感觉运动皮质相对 spared。PSP患者的rCBF在额叶皮质降低。SND患者的rCBF在额叶皮质和小脑降低。使用3D - SSP进行的统计学rCBF分析是锥体外系疾病早期鉴别诊断的一项有用指标。 （注：原文中spared可能有误，推测为spared，意为“ spared”，可根据实际情况修改。）
