Kageyama H, Kikuchi S, Tashiro K
Department of Neurology, National Hokkaido Daiichi Hospital.
Nihon Rinsho. 1997 Jan;55(1):238-42.
We studied regional cerebral blood flow (rCBF) in 8 patients with non-demented Parkinson's disease (PD). 1 patient with progressive supranuclear palsy (PSP), 1 patient with multiple system atrophy (MSA), and 7 normal control subjects using single photon emission computed tomography (SPECT) with the IMP-ARG method. Regions of interest were studied in the cerebral cortex (upper frontal, lower frontal, temporal, occipital, parietal), thalamus, basal ganglia, and cerebellum. In patients with PD, rCBF was normal in 4/8, and decreased in occipital lobe in 4/8. In patient with PSP, rCBF was decreased in the upper and lower frontal lobes, and in the cerebellum. In patient with MSA, rCBF was diminished in the cerebellum. The results of our study were almost compatible with the conventional rCBF study by positron emission tomography (PET), however, the decrease of rCBF in occipital lobe had rarely been reported, suggesting that might be related to visuospatial dysfunction in Parkinson's disease.
我们使用IMP-ARG方法，通过单光子发射计算机断层扫描（SPECT）对8例非痴呆型帕金森病（PD）患者、1例进行性核上性麻痹（PSP）患者、1例多系统萎缩（MSA）患者以及7名正常对照者的局部脑血流量（rCBF）进行了研究。对大脑皮质（额上回、额下回、颞叶、枕叶、顶叶）、丘脑、基底神经节和小脑的感兴趣区域进行了研究。在PD患者中，8例中有4例rCBF正常，8例中有4例枕叶rCBF降低。在PSP患者中，额上回和额下回以及小脑的rCBF降低。在MSA患者中，小脑的rCBF减少。我们的研究结果与传统的正电子发射断层扫描（PET）rCBF研究结果基本相符，然而，枕叶rCBF降低的情况鲜有报道，提示这可能与帕金森病的视觉空间功能障碍有关。
