胆碱能阻滞不会改变对刺激性激发的鼻充血反应。

Cholinergic blockade does not alter the nasal congestive response to irritant provocation.

作者信息

Shusterman Dennis, Murphy Mary-Alice, Walsh Paula, Balmes John R

机构信息

Division of Occupational and Environmental Medicine, University of California, San Francisco, USA.

出版信息

Rhinology. 2002 Sep;40(3):141-6.

PMID:12357714

Abstract

OBJECTIVE

To understand the mechanism underlying the nasal congestive response to irritant challenge.

METHODS

We exposed 22 subjects--8 with seasonal allergic rhinitis (SAR), 6 with perennial allergic rhinitis (PAR), and 8 normals--to chlorine (Cl2) gas (1.0 ppm x 15 min.) by nasal CPAP mask. Control exposures (filtered air) were carried out on separate days, with counter-balancing of exposure order. Nasal airway resistance (NAR) was measured in triplicate before and after the provocation sequence using active posterior rhinomanometry. For each subject, this experiment was repeated twice, after [double-blinded] pre-treatment with: 1) ipratropium bromide (IB) 0.6% nasal spray, and 2) vehicle.

RESULTS

As a group, allergic rhinitics (SAR + PAR) showed greater [Cl2] exposure-related increases in NAR than did normals on placebo (vehicle) pretreatment days (p < 0.05). IB pre-treatment, however, did not have a systematic effect on Cl2-induced congestion.

CONCLUSION

Cholinergic mechanisms do not appear to be responsible for the nasal congestive response to irritant provocation.

摘要

目的

了解对刺激性激发产生鼻充血反应的潜在机制。

方法

我们通过鼻持续气道正压通气面罩，让22名受试者（8名季节性变应性鼻炎患者、6名常年性变应性鼻炎患者和8名正常人）暴露于氯气（Cl2）气体（1.0 ppm，持续15分钟）中。在不同日期进行对照暴露（过滤空气），并对暴露顺序进行交叉平衡。在激发序列前后，使用主动后鼻测压法对鼻气道阻力（NAR）进行三次测量。对每名受试者，在[双盲]预处理后重复该实验两次，预处理分别为：1）0.6%异丙托溴铵（IB）鼻喷雾剂，2）赋形剂。