Ciprandi Giorgio, Cirillo Ignazio, Vizzaccaro Andrea, Pallestrini Eugenio, Tosca Maria Angela
Ospedale San Martino, Genoa, Italy.
Am J Rhinol. 2006 Mar-Apr;20(2):224-6.
Rhinomanometry measures nasal airflow that is frequently impaired in allergic rhinitis. Decongestion tests consist of spraying an intranasal vasoconstrictor drug to evaluate the reversibility of nasal airflow limitation. The aim of this study was to evaluate the decongestion test in patients with seasonal allergic rhinitis (SAR) caused by pollen sensitization, perennial allergic rhinitis (PAR) caused by sensitization to perennial allergens only, or mixed allergic rhinitis (MAR) caused by sensitization to both allergens.
One hundred twenty-three subjects (112 men and 11 women, mean age, 22.9 +/- 5.7 years) were studied; 40 subjects had PAR, 43 subjects had MAR, and 40 subjects had SAR. Total symptom score (including: nasal itching, sneezing, rhinorrhea, and nasal obstruction) was assessed. Rhinomanometry and decongestion tests were performed in all subjects.
Nasal symptom severity was superimposable in the three groups (p was not significant). After decongestion tests, an increase of nasal airflow and a decrease of nasal resistance was shown in PAR (p < 0.01), MAR (p < 0.001), and SAR subjects (p < 0.001). The intergroup analysis showed that SAR patients had less reversibility than PAR (p < 0.01).
This study provides the first evidence of the different response to decongestion tests, taking into consideration the causal allergens.
鼻阻力测量法可测量鼻气流，而鼻气流在过敏性鼻炎中常受损。减充血试验包括喷洒鼻内血管收缩药物以评估鼻气流受限的可逆性。本研究的目的是评估对由花粉致敏引起的季节性过敏性鼻炎（SAR）、仅对常年性变应原致敏引起的常年性过敏性鼻炎（PAR）或对两种变应原均致敏引起的混合性过敏性鼻炎（MAR）患者进行的减充血试验。
对123名受试者（112名男性和11名女性，平均年龄22.9±5.7岁）进行了研究；40名受试者患有PAR，43名受试者患有MAR，40名受试者患有SAR。评估总症状评分（包括：鼻痒、打喷嚏、流涕和鼻塞）。对所有受试者进行鼻阻力测量法和减充血试验。
三组的鼻部症状严重程度相当（p无显著性差异）。减充血试验后，PAR组（p<0.01）、MAR组（p<0.001）和SAR组受试者（p<0.001）的鼻气流增加，鼻阻力降低。组间分析显示，SAR患者的可逆性低于PAR患者（p<0.01）。
本研究首次提供了考虑致病变应原后对减充血试验不同反应的证据。
