Rapid hydrolytic cleavage of the mRNA model compound HPNP by glycine based macrocyclic lanthanide ribonuclease mimics.
作者信息
Gunnlaugsson Thorfinnur, Davies R Jeremy H, Nieuwenhuyzen Mark, Stevenson Clarke S, Viguier Romain, Mulready Sinead
机构信息
Department of Chemistry, Trinity College Dublin, Dublin 2, Ireland.
出版信息
Chem Commun (Camb). 2002 Sep 21(18):2136-7. doi: 10.1039/b205349g.
DOI:10.1039/b205349g
PMID:12357812
Abstract
The lanthanide ion based macrocyclic complexes 1.Ln mimic the hydrophobic nature of ribonucleases, where the lanthanide ions induce the formation of a hydrophobic cavity for 1, giving rise to a large order of magnitude enhancement in the hydrolytic cleavage of HPNP.
摘要
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