• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

调节基于环糊精的镧系元素配合物用于磷酸二酯水解的性质；碱性辅助因子的作用。

Tuning the properties of cyclen based lanthanide complexes for phosphodiester hydrolysis; the role of basic cofactors.

作者信息

Fanning Ann-Marie, Plush Sally E, Gunnlaugsson Thorfinnur

机构信息

School of Chemistry, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland.

出版信息

Chem Commun (Camb). 2006 Sep 28(36):3791-3. doi: 10.1039/b609923h. Epub 2006 Aug 22.

DOI:10.1039/b609923h
PMID:16969459
Abstract

The synthesis of several cyclen based lanthanide [Eu(III) and La(III)] complexes is described; these metallo ribonuclease mimics are based on the use of alkyl amines as pendent arms, which give rise to fast hydrolysis within the physiological pH range of HPNP (an RNA model compound) that is highly dependent on the length of the alkyl spacer.

摘要

描述了几种基于环糊精的镧系元素（铕（III）和镧（III））配合物的合成；这些金属核糖核酸酶模拟物基于使用烷基胺作为侧臂，这导致在HPNP（一种RNA模型化合物）的生理pH范围内快速水解，其高度依赖于烷基间隔基的长度。

相似文献

1
Tuning the properties of cyclen based lanthanide complexes for phosphodiester hydrolysis; the role of basic cofactors.调节基于环糊精的镧系元素配合物用于磷酸二酯水解的性质；碱性辅助因子的作用。
Chem Commun (Camb). 2006 Sep 28(36):3791-3. doi: 10.1039/b609923h. Epub 2006 Aug 22.
2
Tri- and tetra-substituted cyclen based lanthanide(III) ion complexes as ribonuclease mimics: a study into the effect of log Ka, hydration and hydrophobicity on phosphodiester hydrolysis of the RNA-model 2-hydroxypropyl-4-nitrophenyl phosphate (HPNP).基于三取代和四取代环糊精的镧系(III)离子配合物作为核糖核酸酶模拟物：关于log Ka、水合作用和疏水性对RNA模型2-羟丙基-4-硝基苯基磷酸酯(HPNP)磷酸二酯水解影响的研究。
Org Biomol Chem. 2015 May 28;13(20):5804-16. doi: 10.1039/c4ob02384f.
3
Rapid hydrolytic cleavage of the mRNA model compound HPNP by glycine based macrocyclic lanthanide ribonuclease mimics.
Chem Commun (Camb). 2002 Sep 21(18):2136-7. doi: 10.1039/b205349g.
4
Synthesis and characterisation of bis-cyclen based dinuclear lanthanide complexes.基于双环烯的双核镧系配合物的合成与表征
Org Biomol Chem. 2006 Apr 21;4(8):1572-9. doi: 10.1039/b514106k. Epub 2006 Mar 14.
5
Responsive lanthanide luminescent cyclen complexes: from switching/sensing to supramolecular architectures.响应性镧系发光大环配合物：从切换/传感到超分子结构
Chem Commun (Camb). 2005 Jul 7(25):3114-31. doi: 10.1039/b418196d. Epub 2005 Jun 1.
6
Phosphodiester hydrolysis by lanthanide complexes of bis-tris propane.
Inorg Chem. 2001 Jul 16;40(15):3786-96. doi: 10.1021/ic0010205.
7
Synthesis of luminescent homo-dinuclear cationic lanthanide cyclen complexes bearing amide pendant arms through the use of copper catalysed (1,3-Huisgen, CuAAC) click chemistry.通过使用铜催化的（1,3-希夫碱，CuAAC）点击化学，合成带有酰胺侧臂的发光同核双阳离子镧系元素环戊二烯配合物。
Org Biomol Chem. 2012 Jan 14;10(2):314-22. doi: 10.1039/c1ob06203d. Epub 2011 Nov 9.
8
Synthesis, potentiometric, kinetic, and NMR Studies of 1,4,7,10-tetraazacyclododecane-1,7-bis(acetic acid)-4,10-bis(methylenephosphonic acid) (DO2A2P) and its complexes with Ca(II), Cu(II), Zn(II) and lanthanide(III) ions.1,4,7,10-四氮杂环十二烷-1,7-双（乙酸）-4,10-双（亚甲基膦酸）（DO2A2P）及其与Ca(II)、Cu(II)、Zn(II)和镧系(III)离子配合物的合成、电位、动力学和核磁共振研究
Inorg Chem. 2008 May 5;47(9):3851-62. doi: 10.1021/ic7024704. Epub 2008 Apr 2.
9
19F NMR based pH probes: lanthanide(III) complexes with pH-sensitive chemical shifts.基于19F核磁共振的pH探针：具有pH敏感化学位移的镧系（III）配合物。
Chem Commun (Camb). 2008 Jun 14(22):2514-6. doi: 10.1039/b802838a. Epub 2008 May 1.
10
Cyclen lanthanide-based micellar structures for application as luminescent [Eu(iii)] and magnetic [Gd(iii)] resonance imaging (MRI) contrast agents.用于作为发光[铕（III）]和磁性[钆（III）]磁共振成像（MRI）造影剂的基于轮环配体镧系元素的胶束结构。
Chem Commun (Camb). 2016 Sep 18;52(72):10858-61. doi: 10.1039/c6cc03092k. Epub 2016 Aug 15.

引用本文的文献

1
Effects of the Metal Ion on the Mechanism of Phosphodiester Hydrolysis Catalyzed by Metal-Cyclen Complexes.金属离子对金属环配合物催化磷酸二酯水解机理的影响。
Front Chem. 2019 Apr 5;7:195. doi: 10.3389/fchem.2019.00195. eCollection 2019.