Hillyer M H, Taylor F G R, Proudman C J, Edwards G B, Smith J E, French N P
Equine Centre, Department of Clinical Veterinary Science, University of Bristol, Langford, Somerset, UK.
Equine Vet J. 2002 Jul;34(5):455-63. doi: 10.2746/042516402776117746.
A case control study was performed to identify risk factors for colic caused by simple colonic obstruction and distension (SCOD) in the horse. Case horses were recruited from 2 veterinary school clinics. Control horses were population based and matched by time of year. A number of risk factors were considered in the following areas: general carer and premises information; exercise information; husbandry information (housing- and pasture-related); feeding information; breeding information; behavioural information; travel information; preventive medicine information and previous medical information. All variables with a P value of <0.2 in the univariable analysis were considered for possible inclusion in a multivariable model. A final model, produced by a forward stepwise method, identified crib-biting or windsucking, an increasing number of hours spent in a stable, a recent change in a regular exercise programme, the absence of administration of an ivermectin or moxidectin anthelmintic in the previous 12 months and a history of travel in the previous 24 h as associated with a significantly increased risk of SCOD. An alternative final model, produced by a backwards elimination method, identified the same variables as the forward model with, in addition, a history of residing on the current establishment for less than 6 months, a history of a previous colic episode and the fewer times per year the teeth were checked/treated as associated with a significantly increased risk of SCOD. Three of the risk factors in this model were associated with a large increase in risk: stabling for 24 h/day, crib-biting/windsucking and travel in the previous 24 h.
开展了一项病例对照研究,以确定马因单纯性结肠梗阻和扩张(SCOD)导致绞痛的风险因素。病例马从2家兽医学院诊所招募。对照马以群体为基础,并按年份进行匹配。在以下方面考虑了一些风险因素:一般护理人员和场所信息;运动信息;饲养管理信息(与住房和牧场相关);喂养信息;繁殖信息;行为信息;旅行信息;预防医学信息和既往病史。单变量分析中P值<0.2的所有变量都被考虑是否可能纳入多变量模型。通过向前逐步法生成的最终模型确定,咬栏或咽气癖、在马厩中停留时间增加、近期常规运动计划的改变、过去12个月未使用伊维菌素或莫西菌素驱虫药以及过去24小时内有旅行史与SCOD风险显著增加相关。通过向后剔除法生成的另一个最终模型确定了与向前模型相同的变量,此外,在当前场所居住少于6个月的历史、既往绞痛发作史以及每年检查/治疗牙齿的次数较少与SCOD风险显著增加相关。该模型中的三个风险因素与风险大幅增加相关:每天在马厩中停留24小时、咬栏/咽气癖以及过去24小时内有旅行史。