Sundfeldt Mikael, Widmark Michael, Johansson Carina B, Campbell Patricia, Carlsson Lars V
Department of Biomaterials/Handicap Research, Göteborg, Sweden.
Acta Orthop Scand. 2002 Aug;73(4):416-24. doi: 10.1080/00016470216314.
In a rabbit model of a weight bearing, articulating prosthetic joint we repeatedly injected submicron particles of Ultra-High-Molecular-Weight-Polyethylene (UHMWPE) produced in a hip simulator. The contralateral knee with the same prosthesis was injected with carrier (NaCl) without UHMWPE. Histomorphometrical studies on undecalcified cut and ground sections at 26 and 42 weeks involved quantifications of the entire bone to metal contact and the bone area around each implant. We found no statistically significant differences between test and control groups, and the UHMWPE debris did not induce any significant osteolysis, indicating that an osseointegrated implant with a sealed interface may not be affected by UHMWPE debris or progress to aseptic loosening.
在一个负重的人工关节兔模型中，我们反复向关节假体注入在髋关节模拟器中产生的超高分子量聚乙烯（UHMWPE）亚微米颗粒。对侧植入相同假体的膝关节则注入不含UHMWPE的载体（氯化钠）。在26周和42周时，对未脱钙的切割和磨片进行组织形态计量学研究，包括对整个骨与金属接触面积以及每个植入物周围骨面积的量化分析。我们发现试验组和对照组之间没有统计学上的显著差异，并且UHMWPE碎片未引起任何显著的骨溶解，这表明具有密封界面的骨整合植入物可能不会受到UHMWPE碎片的影响，也不会发展为无菌性松动。
