石棉尘对大鼠肺部造成的生化变化。

Biochemical changes caused by asbestos dust in the lungs of rats.

作者信息

Rahman Q, Viswanathan P N, Zaidi S H

出版信息

Scand J Work Environ Health. 1975 Mar;1(1):50-3. doi: 10.5271/sjweh.2860.

Abstract

The contents of collagen, hexosamine, phospholipids, and cholesterol and the activities of acid and alkaline phosphatases, glutamic oxalo-acetate transaminase, glutamic pyruvate transminase, aldolase, hexokinase, and lactic dehydrogenase were determined in the lungs of rats 150 days after the intratracheal injection of amosite, anthophyllite, and chyrsotile. Anthophyllite did not cause any significant change, while amosite and chrysotile caused significant increases in the contents of collagen and mucopolysaccharides. Lactic dehydrogenase and acid phosphatase activities were increased by all the dusts, while the othe enzymes were not seriously affected. The biochemical significance of the findings in relation to abestosis was discussed.

摘要

在气管内注入铁石棉、直闪石和温石棉150天后的大鼠肺中，测定了胶原蛋白、氨基己糖、磷脂、胆固醇的含量以及酸性和碱性磷酸酶、谷草转氨酶、谷丙转氨酶、醛缩酶、己糖激酶和乳酸脱氢酶的活性。直闪石未引起任何显著变化，而铁石棉和温石棉导致胶原蛋白和粘多糖含量显著增加。所有粉尘均使乳酸脱氢酶和酸性磷酸酶活性增加，而其他酶未受到严重影响。讨论了这些发现与石棉沉着病相关的生化意义。