Shibata C, Naito H, Ueno T, Jin X-L, Funayama Y, Fukushima K, Matsuno S, Sasaki I
Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University School of Medicine, Sendai, Japan.
Neurogastroenterol Motil. 2002 Oct;14(5):543-51. doi: 10.1046/j.1365-2982.2002.00358.x.
The aim was to study the effect of intraduodenal capsaicin on interdigestive gastric contractions. Mongrel dogs were equipped with strain-gauge force transducers to measure gastroduodenal motility. The effects of intraduodenal capsaicin with or without pharmacological antagonists on spontaneous and motilin-induced interdigestive gastric contractions and on plasma motilin were studied in dogs with intact stomachs. The effect of intraduodenal capsaicin on gastric contractions was also studied in vagally denervated gastric (Heidenhain) pouch and vagally innervated antral pouch. Intraduodenal capsaicin inhibited spontaneous and motilin-induced gastric contractions. The spontaneous peak in plasma motilin was inhibited by intraduodenal capsaicin. The effect of intraduodenal capsaicin on motilin-induced gastric contractions was not affected by blockade of nitric oxide synthase, or by beta-adrenoceptor antagonist. Administration of alpha-adrenergic blocker inhibited basal interdigestive gastric motility. Intraduodenal capsaicin had no effect on contractions in the Heidenhain pouch but inhibited those in vagally innervated antral pouch. Duodenal afferent fibres stimulated by capsaicin inhibit gastric contractions via a nitric oxide-independent extrinsic neural reflex.
目的是研究十二指肠内注入辣椒素对消化间期胃收缩的影响。杂种犬安装应变片式力传感器以测量胃十二指肠运动。在胃完整的犬中，研究十二指肠内注入辣椒素（有无药理学拮抗剂）对自发性和胃动素诱导的消化间期胃收缩以及血浆胃动素的影响。还在迷走神经切断的胃（海登海因）小胃和迷走神经支配的胃窦小胃中研究十二指肠内注入辣椒素对胃收缩的影响。十二指肠内注入辣椒素可抑制自发性和胃动素诱导的胃收缩。十二指肠内注入辣椒素可抑制血浆胃动素的自发性峰值。十二指肠内注入辣椒素对胃动素诱导的胃收缩的影响不受一氧化氮合酶阻断或β-肾上腺素能受体拮抗剂的影响。给予α-肾上腺素能阻滞剂可抑制基础消化间期胃动力。十二指肠内注入辣椒素对海登海因小胃的收缩无影响，但可抑制迷走神经支配的胃窦小胃的收缩。辣椒素刺激的十二指肠传入纤维通过不依赖一氧化氮的外在神经反射抑制胃收缩。
