Shibata Chikashi, Jin Xue-Lin, Naito Hiroo, Matsuno Seiki, Sasaki Iwao
Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Gastroenterology. 2002 Dec;123(6):1904-11. doi: 10.1053/gast.2002.37057.
BACKGROUND & AIMS: The aim of the present study was to determine the effect of intraileal administration of capsaicin on gastrointestinal motility.
Mongrel dogs equipped with strain gauge force transducers on the stomach, small intestine, and colon were used. We studied the effects of intraileal capsaicin on gastrointestinal contractions with or without pharmacologic antagonists. The effects of capsaicin administration into the lumen of innervated and extrinsically denervated ileal Thiry loops were also studied.
Intraileal capsaicin dose dependently inhibited postprandial contractions at all sites and interdigestive contractions in the upper gastrointestinal tract. Intraileal capsaicin-induced inhibition of gastrointestinal contractions was partially reversed by a nitric oxide (NO) synthase inhibitor, a 5 hydroxytryptamine-3 receptor antagonist (5-HT(3)), and an opiate antagonist. Administration of capsaicin into the innervated ileal Thiry loop had inhibitory effects on gastrointestinal contractions, but gastrointesinal motor activity was not affected by capsaicin administered into the extrinsically denervated Thiry loop.
Stimulation of ileal afferent fibers by capsaicin inhibits gastrointestinal contractions via an extrinsic neural reflex.
本研究旨在确定回肠内给予辣椒素对胃肠动力的影响。
使用在胃、小肠和结肠配备应变片式力传感器的杂种犬。我们研究了回肠内给予辣椒素对有无药理学拮抗剂时胃肠收缩的影响。还研究了将辣椒素注入有神经支配和去外在神经支配的回肠Thiry袢肠腔内的作用。
回肠内给予辣椒素剂量依赖性地抑制所有部位的餐后收缩以及上消化道的消化间期收缩。回肠内给予辣椒素引起的胃肠收缩抑制被一氧化氮（NO）合酶抑制剂、5-羟色胺-3受体拮抗剂（5-HT(3)）和阿片类拮抗剂部分逆转。将辣椒素注入有神经支配的回肠Thiry袢对胃肠收缩有抑制作用，但将辣椒素注入去外在神经支配的Thiry袢对胃肠运动活性无影响。
辣椒素刺激回肠传入纤维通过外在神经反射抑制胃肠收缩。
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