惊恐障碍中儿茶酚-O-甲基转移酶基因多态性
Catechol O-methyltransferase genetic polymorphism in panic disorder.
作者信息
Woo Jong-Min, Yoon Kyung-Sik, Yu Bum-Hee
机构信息
Department of Neuropsychiatry, Seoul Paik Hospital, Inje University, Seoul, Korea.
出版信息
Am J Psychiatry. 2002 Oct;159(10):1785-7. doi: 10.1176/appi.ajp.159.10.1785.
OBJECTIVE
The authors examined the distribution of catechol O-methyltransferase (COMT) genotypes in patients with panic disorder as well as the relationship between a COMT polymorphism and the clinical characteristics of these patients.
METHOD
Fifty-one patients with panic disorder and 45 healthy comparison subjects were tested for a genetic polymorphism of COMT. Clinical variables were assessed for the patients with panic disorder.
RESULTS
The frequency of the L/L genotype was significantly higher in the patients with panic disorder than in the healthy subjects (19.6% versus 2.2%). Panic disorder was significantly associated with the L allele and L/L genotype. Patients with panic disorder who had the L/L genotype showed poorer treatment response than those with other genotypes.
CONCLUSIONS
These results suggest that the L/L genotype of the COMT gene may be related to the development and treatment outcome of panic disorder in some patients.
目的
作者研究了惊恐障碍患者中儿茶酚-O-甲基转移酶（COMT）基因型的分布情况，以及COMT基因多态性与这些患者临床特征之间的关系。
方法
对51例惊恐障碍患者和45名健康对照者进行了COMT基因多态性检测。对惊恐障碍患者的临床变量进行了评估。
结果
惊恐障碍患者中L/L基因型的频率显著高于健康受试者（19.6%对2.2%）。惊恐障碍与L等位基因和L/L基因型显著相关。具有L/L基因型的惊恐障碍患者比其他基因型患者的治疗反应更差。
结论
这些结果表明，COMT基因的L/L基因型可能与部分患者惊恐障碍的发生及治疗结果有关。
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