Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.
Center of Genetics and Life Sciences, Sirius University of Science and Technology, 354340 Sochi, Russia.
Genes (Basel). 2020 Nov 4;11(11):1310. doi: 10.3390/genes11111310.
(1) Background: Although panic disorder (PD) is one of the most common anxiety disorders severely impacting quality of life, no effective genetic testing exists; known data on possible genetic biomarkers is often scattered and unsystematic which complicates further studies. (2) Methods: We used PathwayStudio 12.3 (Elsivier, Netherlands) to acquire literature data for further manual review and analysis. 229 articles were extracted, 55 articles reporting associations, and 32 articles reporting no associations were finally selected. (3) Results: We provide exhaustive information on genetic biomarkers associated with PD known in the scientific literature. Data is presented in two tables. Genes and may be considered the most promising for PD diagnostic to date. (4) Conclusions: This review illustrates current progress in association studies of PD and may indicate possible molecular mechanisms of its pathogenesis. This is a possible basis for data analysis, novel experimental studies, or developing test systems and personalized treatment approaches.
(1) 背景：尽管恐慌障碍（PD）是一种常见的严重影响生活质量的焦虑障碍，但目前尚无有效的遗传检测方法；已知的可能遗传生物标志物数据通常分散且不系统，这使得进一步的研究变得复杂。
(2) 方法：我们使用 PathwayStudio 12.3（荷兰爱思唯尔）获取文献数据，以便进一步进行手动审查和分析。共提取了 229 篇文章，最终选择了 55 篇报告关联的文章和 32 篇报告无关联的文章。
(3) 结果：我们提供了有关科学文献中已知与 PD 相关的遗传生物标志物的详尽信息。数据以两个表格的形式呈现。迄今为止，基因和可能被认为是 PD 诊断最有前途的候选基因。
(4) 结论：本综述说明了 PD 关联研究的最新进展，并可能提示其发病机制的可能分子机制。这可能是数据分析、新的实验研究或开发测试系统和个性化治疗方法的基础。
