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转录调控元件的分析与功能:来自果蝇的见解

Analysis and function of transcriptional regulatory elements: insights from Drosophila.

作者信息

Arnosti David N

机构信息

Department of Biochemistry and Molecular Biology and Program in Genetics, Michigan State University, East Lansing, Michigan 48824-1319, USA.

出版信息

Annu Rev Entomol. 2003;48:579-602. doi: 10.1146/annurev.ento.48.091801.112749. Epub 2001 Sep 28.

Abstract

Analysis of gene expression is assuming an increasingly important role in elucidating the molecular basis of insect biology. Transcriptional regulation of gene expression is directed by a variety of cis-acting DNA elements that control spatial and temporal patterns of expression. This review summarizes current knowledge about properties of transcriptional regulatory elements, based largely on research in Drosophila melanogaster, and outlines ways that new technologies are providing tools to facilitate the study of transcriptional regulatory elements in other insects.

摘要

基因表达分析在阐明昆虫生物学的分子基础方面正发挥着越来越重要的作用。基因表达的转录调控由多种顺式作用DNA元件指导,这些元件控制着基因表达的时空模式。本综述主要基于对黑腹果蝇的研究,总结了目前关于转录调控元件特性的知识,并概述了新技术为促进其他昆虫转录调控元件研究提供工具的方式。

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