Izmirova N, Benchev I
Probl Khig. 1975;1:45-8.
The splitting of Sayphos into metabolites inhibiting indoxyl acetate esterase activity is investigated. Also the dynamics of Sayphos excretion in the urine is studied. It is established that in the urine of unpoisoned rabbits, normally a compound with Rf 0.79 is contained, inhibiting indoxyl acetate esterase activity. Sayphos and metabolite I with Rf 0.08 are demonstrable both in the blood and urine at 2 hours after peroral introduction of the poison. Within 24 hours no traces of the pesticide and metabolite I are discovered in the blood, and in the urine--within 96 hours since the beginning of the experiment. Most of the indoxyl acetate esterase activity inhibitors (Sayphos and metabolite I), excreted via urine (mean 95%), are emitted up to the 24th hour inclusive.
研究了赛福磷分解为抑制吲哚酚乙酸酯酶活性的代谢产物的情况。还研究了赛福磷在尿液中的排泄动态。已确定在未中毒兔子的尿液中，通常含有一种Rf值为0.79的化合物，它能抑制吲哚酚乙酸酯酶活性。经口摄入毒物2小时后，在血液和尿液中均可检测到赛福磷和Rf值为0.08的代谢产物I。在24小时内，血液中未发现农药和代谢产物I的痕迹，而在尿液中——自实验开始后96小时内未发现。经尿液排泄的大部分吲哚酚乙酸酯酶活性抑制剂（赛福磷和代谢产物I）（平均95%）在包括第24小时在内的时间段内排出。
