Urazova O I, Novitskii V V, Litvinova L S, Pomogaeva A P
Department of Pathophysiology, Department of Childhood Infectious Diseases, Siberian State Medical University, Tomsk.
Bull Exp Biol Med. 2002 Mar;133(3):277-80. doi: 10.1023/a:1015851120812.
Infectious mononucleosis is associated with suppression of lymphocyte apoptosis and accumulation of cells with chromosome aberrations in the peripheral blood. The type and severity of these aberrations do not depend on the etiological variant of infection and patient age. At the same time in 3-6-year-old children with infectious mononucleosis caused by Epstein-Barr virus we observed activation of DNA repair system in lymphoid cells.
传染性单核细胞增多症与淋巴细胞凋亡受抑制以及外周血中出现染色体畸变的细胞蓄积有关。这些畸变的类型和严重程度并不取决于感染的病因变体及患者年龄。与此同时，在由爱泼斯坦-巴尔病毒引起的传染性单核细胞增多症的3至6岁儿童中，我们观察到淋巴细胞中DNA修复系统的激活。
