沙利度胺治疗麻风病。
Thalidomide in the treatment of leprosy.
作者信息
Teo Steve K, Resztak Ken E, Scheffler Michael A, Kook Karin A, Zeldis Jerry B, Stirling David I, Thomas Steve D
机构信息
Celgene Corporation, 7 Powder Horn Drive, Warren, NJ 07059, USA.
出版信息
Microbes Infect. 2002 Sep;4(11):1193-202. doi: 10.1016/s1286-4579(02)01645-3.
Abstract
Leprosy is a chronic infection of the skin and nerves caused by Mycobacterium leprae. Erythema nodosum leprosum (ENL) is a reactive state in lepromatous leprosy. Thalidomide has been used to treat ENL since the 1960s. One of its mechanisms of action is anti-inflammatory through selective inhibition of the pro-inflammatory cytokine TNF-alpha produced by monocytes.
摘要
麻风病是由麻风分枝杆菌引起的皮肤和神经的慢性感染。结节性红斑麻风反应（ENL）是瘤型麻风的一种反应状态。自20世纪60年代以来，沙利度胺一直用于治疗ENL。其作用机制之一是通过选择性抑制单核细胞产生的促炎细胞因子肿瘤坏死因子-α来发挥抗炎作用。
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