Burrell R, Flaherty D K, Schreiber J E
Inhaled Part. 1975 Sep;4 Pt 2:519-29.
A comparative immunological and microbiological study of experimental coalworkers' pneumoconiosis (CWP) was made in rats and mice subjected to long-term exposures of coal-mine dust aerosols. Such aerosols were realistically prepared at a concentration equal to the maximal level of respirable dust permitted by Federal standards and animals were exposed for lengths of time equal to human work contact. Among the factors studied were the production of IgA and lung reactive antibody, lung microflora and changes in pulmonary clearance. Additional experiments were concerned with the effects of passively administered lung antibody on the pulmonary clearance. It was found that both species responded immunologically in a similar manner to humans with CWP in that IgA levels were significantly elevated and lung reactive antibodies were stimulated. Coal-mine dust inhalation had little effect on the pulmonary inactivation of inhaled bacteria, but the concomitant occurrence of passively administered lung reactive antibody seemed to enhance the inactivation.
对长期暴露于煤矿粉尘气溶胶的大鼠和小鼠进行了实验性煤工尘肺（CWP）的比较免疫学和微生物学研究。这些气溶胶的制备浓度符合联邦标准允许的可吸入粉尘最大水平，动物的暴露时间与人类工作接触时间相同。研究的因素包括IgA和肺反应性抗体的产生、肺微生物群以及肺清除率的变化。额外的实验关注被动给予的肺抗体对肺清除率的影响。结果发现，这两个物种在免疫学上对患有CWP的人类有类似反应，即IgA水平显著升高，肺反应性抗体受到刺激。吸入煤矿粉尘对吸入细菌的肺部灭活作用很小，但被动给予的肺反应性抗体的同时出现似乎增强了灭活作用。
