双卵双生的遗传易感性与精神分裂症之间可能存在关联。
A possible association between the genetic predisposition for dizygotic twinning and schizophrenia.
作者信息
Kläning Ulla, Pedersen Carsten Bøcker, Mortensen Preben Bo, Kyvik Kirsten Ohm, Skytthe Axel
机构信息
Centre of Clinical Psychiatric Research, Mood Disorder Research Unit, Psychiatric Hospital in Aarhus, Skovagervej 2, 8240 Risskov, Denmark.
出版信息
Schizophr Res. 2002 Nov 1;58(1):31-5. doi: 10.1016/s0920-9964(01)00343-7.
BACKGROUND
A previous study demonstrated a 40% higher rate of schizophrenia in dizygotic twins than in the general population. The aim of the present study is to evaluate whether genes influencing the rate of dizygotic twinning and genes of importance for developing schizophrenia can be associated.
METHOD
Through record linkage between The Danish Twin Register, The Danish Psychiatric Central Register, and The Danish Civil Registration System, the rate of schizophrenia in singleton siblings of dizygotic and monozygotic twins was compared with the rate in siblings of singletons.
RESULTS
The rate of first admission to hospital for schizophrenia in siblings of dizygotic twins was 35% greater than the rate in siblings of singletons. The result was statistically significant (p = 0.04). The rate in siblings of monozygotic twins was not increased.
CONCLUSION
The results are in accordance with a theory of a linkage between genes influencing the rate of dizygotic twinning and genes influencing the threshold for developing schizophrenia.
背景
先前的一项研究表明，异卵双胞胎患精神分裂症的几率比普通人群高40%。本研究的目的是评估影响异卵双胞胎发生率的基因与对精神分裂症发病具有重要意义的基因是否存在关联。
方法
通过丹麦双胞胎登记册、丹麦精神病学中央登记册和丹麦民事登记系统之间的记录链接，比较了异卵双胞胎和同卵双胞胎的单胎兄弟姐妹中精神分裂症的发病率与单胎兄弟姐妹中的发病率。
结果
异卵双胞胎的兄弟姐妹首次因精神分裂症住院的发生率比单胎兄弟姐妹的发生率高35%。结果具有统计学意义（p = 0.04）。同卵双胞胎的兄弟姐妹的发病率没有增加。
结论
这些结果与一种理论相符，即影响异卵双胞胎发生率的基因与影响精神分裂症发病阈值的基因之间存在联系。
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