Sajatovic Martha, Rosch Debra S, Sivec Harry J, Sultana Dilara, Smith Douglas A, Alamir Samer, Buckley Peter, Bingham C Raymond
Department of Psychiatry, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland, OH 44106, USA.
Psychiatr Serv. 2002 Oct;53(10):1319-21. doi: 10.1176/appi.ps.53.10.1319.
This study assessed symptoms, severity of illness functional level, insight into illness, and attitudes toward medication in a sample of psychiatric patients who were newly admitted to a state hospital. The patients were evaluated before and after treatment with atypical, conventional, or mixed (atypical plus conventional) antipsychotic medication regimens with the Brief Psychiatric Rating Scale (BPRS), the Clinical Global Impression, the Global Assessment of Functioning, the Scale to Assess Unawareness of Mental Disorder, and the Drug Attitude Inventory. Overall, the patients showed significant improvement in symptoms, severity of illness, functional level, and insight into their illness during the course of hospitalization. Their attitudes toward medications changed minimally during treatment. Only the patients who were treated with conventional antipsychotics showed significant improvement in their attitudes toward medication. However, the change was not large enough to differentiate the conventional antipsychotic treatment group from the other treatment groups.
本研究评估了一批新入住州立医院的精神科患者的症状、疾病严重程度、功能水平、对疾病的洞察力以及对药物治疗的态度。使用简明精神病评定量表(BPRS)、临床总体印象量表、功能总体评定量表、精神障碍自知力评定量表和药物态度量表,对患者在接受非典型、传统或混合(非典型加传统)抗精神病药物治疗方案之前和之后进行了评估。总体而言,患者在住院期间的症状、疾病严重程度、功能水平以及对自身疾病的洞察力方面均有显著改善。他们对药物治疗的态度在治疗期间变化极小。只有接受传统抗精神病药物治疗的患者在对药物治疗的态度上有显著改善。然而,这种变化幅度不足以将传统抗精神病药物治疗组与其他治疗组区分开来。