Tatsui Cláudio Esteves, Koerbel Andrei, Prevedello Daniel Monte-Serrat, Araújo João Candido, Ditzel Léo Fernando Silva, Bleggi-Torres Luis Fernando
Serviço de Neurocirurgia, Hospital Nossa Senhora das Graças, Curitiba, PR, Brasil.
Arq Neuropsiquiatr. 2002 Sep;60(3-B):852-5.
Granulocytic sarcoma is a solid tumor, composed by granulocytic precursor cells at various levels of differentiation, located at an extra-medullary site. It is associated with acute myeloid leukemia, and its presence reveals a bad prognostic factor. The treatment usually consists of radiotherapy and chemotherapy. A case of an intracranial granulocytic sarcoma occurring six months after a bone marrow transplant in a patient with acute myeloid leukemia is reported. The patient presented with headache and left hemiplegia caused by a large fronto-parietal lesion with significant mass effect. After a complete surgical resection there was a full recovery of the deficit. The patient completed radiotherapy and chemotherapy with no evidence of disease after three months of follow-up. Surgery is indicated in the presence of progressive neurological deficit. Surgical decompression may provide rapid improvement and therefore, affect quality of survival.
粒细胞肉瘤是一种实体瘤,由处于不同分化水平的粒细胞前体细胞组成,位于髓外部位。它与急性髓系白血病相关,其出现提示预后不良。治疗通常包括放疗和化疗。本文报道了1例急性髓系白血病患者在骨髓移植6个月后发生颅内粒细胞肉瘤的病例。该患者因额顶叶巨大病变伴明显占位效应出现头痛和左侧偏瘫。在完整手术切除后,缺损完全恢复。患者完成放疗和化疗,随访3个月后无疾病证据。出现进行性神经功能缺损时应行手术治疗。手术减压可迅速改善症状,从而影响生存质量。