Khalid Safoorah, Adil Salman Naseem, Vaziri Irfan Ahmed
Departmens of Pathology, Aga Khan University Hospital, Pakistan.
Indian J Pathol Microbiol. 2007 Jan;50(1):88-90.
Granulocytic sarcoma is an extramedullary tumor composed of immature granulocytic precursor cells. The most common sites of presentation are bone, periosteum, soft tissue, lymph node, skin, and infrequently small intestine. The tumor may develop during the course of acute myeloid leukemia, chronic myeloid leukemia or other myelodysplastic disorders. It can occur without blood or bone marrow manifestations of leukemia and in this case, the diagnosis is difficult. Our patient was initially diagnosed as a case of T-cell non Hodgkin's lymphoma and received one cycle of CHOP with only transient improvement in his symptoms. Subsequently, his biopsy slides were reviewed at our centre and were reported as granulocytic sarcoma.
粒细胞肉瘤是一种由未成熟粒细胞前体细胞组成的髓外肿瘤。最常见的发病部位是骨骼、骨膜、软组织、淋巴结、皮肤,小肠较少见。该肿瘤可在急性髓系白血病、慢性髓系白血病或其他骨髓增生异常综合征病程中发生。它也可在无白血病的血液或骨髓表现的情况下出现,此时诊断较为困难。我们的患者最初被诊断为T细胞非霍奇金淋巴瘤,并接受了一个周期的CHOP方案治疗,症状仅短暂改善。随后,他的活检切片在我们中心进行了复查,报告为粒细胞肉瘤。