Obara Harue, Nishimura Shinjitsu, Hayashi Nakamasa, Numagami Yoshihiro, Inoue Tomoo, Kubo Kohmei, Kaimori Mitsuomi, Nishijima Michiharu
Department of Neurosurgery, Aomori Prefectural Central Hospital. 2-1-1 Higashi-tsukurimichi, Aomori 030-8553, Japan.
No To Shinkei. 2006 Sep;58(9):797-801.
Granulocytic sarcoma (GS) is extramedullary tumor composed of immature leukemic cells. GS is presenting usually as a complication during the course of hematologic neoplasm, such as acute myeloblastic leukemia as well as myeloproliferative and myelodysplastic syndrome. The tumor was also called chroloma based on the green color of the tumorous mass. Central nervous system manifestations of GS are extremely rare. We report a 41-year-old man with acute leukemia type M7, who developed GS in the right occipital lobe after complete remission was achieved. Operative findings revealed the color of the hard tumor was greenish, which suggested the tumor was chroloma. Histological findings showed the tumor was GS. The majority of reported cases of GS in acute myeloid leukemia were M2 FAB classification and have chromosome translocation. Our patient was M7 FAB classification, not have specific chromosome translocation. GS occurrence in AML: M7 patient was extremely rare. This is the first case report of AML: M7 with GS in the central nervous system.
粒细胞肉瘤（GS）是一种由未成熟白血病细胞组成的髓外肿瘤。GS通常表现为血液系统肿瘤病程中的一种并发症，如急性髓细胞白血病以及骨髓增殖性和骨髓增生异常综合征。该肿瘤因其肿块呈绿色也曾被称为绿色瘤。GS的中枢神经系统表现极为罕见。我们报告一例41岁的M7型急性白血病男性患者，在达到完全缓解后右枕叶出现了GS。手术所见显示硬肿瘤的颜色呈绿色，提示该肿瘤为绿色瘤。组织学检查结果显示该肿瘤为GS。急性髓细胞白血病中报道的大多数GS病例为FAB分类的M2型且有染色体易位。我们的患者为FAB分类的M7型，没有特定的染色体易位。GS在急性髓系白血病M7患者中极为罕见。这是首例急性髓系白血病M7合并中枢神经系统GS的病例报告。
