乳腺多形性小叶癌。病例报告。
Pleomorphic lobular carcinoma of the breast. A case report.
作者信息
Gangane Nitin, Shivkumar V B, Sharma Satish
机构信息
Department of Pathology, Mahatma Gandhi Institute of Medical Sciences, Sevagram 442102, Wardha, Maharashtra, India.
出版信息
Acta Cytol. 2002 Sep-Oct;46(5):909-11. doi: 10.1159/000327069.
BACKGROUND
Pleomorphic lobular carcinoma of the breast is associated with aggressive behavior.
CASE
Fine needle aspiration cytology was performed on a breast lump in a 55-year-old woman. The aspirates showed highly pleomorphic, large cells in a dyscohesive pattern, with a tendency of few cells to aggregate in small groups. A diagnosis of ductal carcinoma was made on cytology. On histology, the paraffin sections showed features of pleomorphic lobular carcinoma of the breast.
CONCLUSION
The cytologic features of pleomorphic lobular carcinoma overlap with those of infiltrating ductal carcinoma. It is very difficult to make a diagnosis of pleomorphic lobular carcinoma prospectively on cytology. However, if Indian file arrangement and cytoplasmic vacuolation are present, pleomorphic lobular carcinoma must at least be suggested for the differential diagnosis as it has different clinical implications.
背景
乳腺多形性小叶癌与侵袭性行为相关。
病例
对一名55岁女性乳房肿块进行细针穿刺细胞学检查。吸出物显示高度多形性的大细胞，呈分散模式，少数细胞有聚集成小团的倾向。细胞学诊断为导管癌。组织学检查显示，石蜡切片具有乳腺多形性小叶癌的特征。
结论
多形性小叶癌的细胞学特征与浸润性导管癌重叠。在细胞学上前瞻性诊断多形性小叶癌非常困难。然而，如果存在印度排状排列和细胞质空泡化，必须至少提示多形性小叶癌进行鉴别诊断，因为它具有不同的临床意义。
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