Auger M, Hüttner I
Department of Pathology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.
Cancer. 1997 Feb 25;81(1):29-32. doi: 10.1002/(sici)1097-0142(19970225)81:1<29::aid-cncr7>3.0.co;2-b.
The pleomorphic variant of invasive lobular carcinoma shares the typical infiltrating histologic pattern of classic invasive lobular carcinoma, but differs from it in its nuclear pleomorphism and aggressive behavior. The purpose of this study was to describe the fine-needle aspiration (FNA) cytologic findings of the pleomorphic variant of lobular carcinoma and to compare them with those of classic lobular carcinoma.
Among 405 breast FNA performed in 1995, 7 examples of classic infiltrating lobular carcinoma and 4 cases of this neoplasm's pleomorphic variant were identified; all were histologically confirmed. The FNA from three of the four pleomorphic variant cases and from two of the seven classic lobular carcinoma cases were diagnostic of malignancy; these were evaluated for a variety of cytologic criteria, which were graded from 0 to 3.
Although exhibiting many cytologic features in common with the classic type, such as indian files and cytoplasmic vacuoles, the FNA of the pleomorphic variant differed in their tendency to yield greater cellularity, larger cell size, and, particularly, more pleomorphic nuclei.
The FNA cytologic findings of the pleomorphic variant of lobular carcinoma are characteristically hybrid between those of classic lobular carcinoma and ductal carcinoma.
浸润性小叶癌的多形性变体具有经典浸润性小叶癌典型的浸润性组织学模式，但在核多形性和侵袭性行为方面与之不同。本研究的目的是描述小叶癌多形性变体的细针穿刺（FNA）细胞学表现，并将其与经典小叶癌的表现进行比较。
在1995年进行的405例乳腺FNA中，识别出7例经典浸润性小叶癌和4例该肿瘤的多形性变体；所有病例均经组织学证实。4例多形性变体病例中的3例以及7例经典小叶癌病例中的2例的FNA诊断为恶性肿瘤；对这些病例评估了多种细胞学标准，评分从0到3。
尽管多形性变体的FNA表现出许多与经典类型相同的细胞学特征，如印戒样排列和细胞质空泡，但在细胞丰富度、细胞大小，特别是核多形性方面存在差异。
小叶癌多形性变体的FNA细胞学表现典型地介于经典小叶癌和导管癌之间。
