Dabbs D J, Grenko R T, Silverman J F
Department of Pathology, Pennsylvania State University College of Medicine, Hershey 17033.
Acta Cytol. 1994 Nov-Dec;38(6):923-6.
Pleomorphic lobular carcinoma (PLC) of the breast is a subtype of lobular carcinoma of the breast that is well recognized in the surgical pathology literature. Fine needle aspiration (FNA) recognition of this subtype is important, for the subtype characteristically pursues an aggressive clinical course as compared to the classic lobular carcinoma of the breast. The cytologic literature on this entity is nonexistent. We describe the FNA findings in a series of four cases of PLC diagnosed retrospectively, discuss the cytologic features that are useful in the recognition of this entity and the diagnostic pitfalls, and propose classifying these tumors as a high (poor) nuclear grade variant of lobular carcinoma, analogous to the grading scheme in use for aggressive ductal carcinomas.
乳腺多形性小叶癌（PLC）是乳腺小叶癌的一种亚型，在外科病理学文献中已得到充分认识。对该亚型进行细针穿刺抽吸（FNA）识别很重要，因为与经典的乳腺小叶癌相比，该亚型通常具有侵袭性的临床病程。关于这一实体的细胞学文献尚不存在。我们描述了一系列四例经回顾性诊断的PLC的FNA结果，讨论了有助于识别该实体的细胞学特征和诊断陷阱，并建议将这些肿瘤归类为小叶癌的高（差）核级变体，类似于用于侵袭性导管癌的分级方案。
