Kikyo Hideyuki, Ohki Kenichi, Miyashita Yasushi
Department of Physiology, The University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan.
Neuron. 2002 Sep 26;36(1):177-86. doi: 10.1016/s0896-6273(02)00939-x.
The "feeling-of-knowing" (FOK) is a subjective sense of knowing a word before recalling it, and the FOK provides us clues to understanding the mechanisms of human metamemory systems. We investigated neural correlates for the FOK based on the recall-judgment-recognition paradigm. Event-related functional magnetic resonance imaging with a parametric analysis was used. We found activations in left dorsolateral, left anterior, bilateral inferior, and medial prefrontal cortices that significantly increased as the FOK became greater, and the activations remained significant even when the potentially confounding factor of the response latency was removed. Furthermore, we demonstrated that the FOK region in the right inferior frontal gyrus and a subset of the FOK region in the left inferior frontal gyrus are not recruited for successful recall processes, suggesting their particular role in metamemory processing.
“知晓感”（FOK）是指在回忆某个单词之前对其有所了解的主观感觉，知晓感为我们理解人类元记忆系统的机制提供了线索。我们基于回忆 - 判断 - 识别范式研究了知晓感的神经关联。采用了带有参数分析的事件相关功能磁共振成像。我们发现左背外侧、左前侧、双侧下侧和内侧前额叶皮质出现激活，且随着知晓感增强，激活显著增加，即使去除反应潜伏期这一潜在混杂因素后，激活仍显著。此外，我们证明右额下回的知晓感区域和左额下回知晓感区域的一个子集在成功回忆过程中未被激活，这表明它们在元记忆处理中具有特殊作用。
