DNA阵列与神经生物学——新进展与未来走向？

DNA arrays and neurobiology--what's new and what's next?

作者信息

Barlow Carrolee, Lockhart David J

机构信息

The Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.

出版信息

Curr Opin Neurobiol. 2002 Oct;12(5):554-61. doi: 10.1016/s0959-4388(02)00353-7.

DOI:10.1016/s0959-4388(02)00353-7

PMID:12367635

Abstract

Genomic technologies such as DNA microarrays have been used to study biological processes involved in various normal and disease states; in addition, parallel transcriptional profiling methods hold a great deal of promise for the neurosciences. However, such experiments are technically more demanding and there are unique methodological difficulties for their use in the context of neurobiology and the study of central nervous system disorders.

摘要

诸如DNA微阵列之类的基因组技术已被用于研究各种正常和疾病状态下涉及的生物过程；此外，平行转录谱分析方法在神经科学领域有着巨大的前景。然而，此类实验在技术上要求更高，并且在神经生物学以及中枢神经系统疾病研究的背景下使用时存在独特的方法学困难。