Schuckit M A, Daly V, Herrman G, Hineman S
Dis Nerv Syst. 1975 Sep;36(9):516-7.
The correlation between a premenstrual syndrome based on emotional symptoms and primary affective disorder was prospectively studied in 105 college freshmen. Students with premenstrual symptoms were twice as likely as controls to have a history of a serious depressive episodes and twice as likely to have a close family member with depression. Seven percent of women with premenstrual emotional symptoms and none of the controls had an affective episode during the ensuing year. The premenstrual syndrome did not interfere with academic performance and was not associated with any lowering of professional aspirations. The inconsistent results of past research on the relationship between depressive disorder and premenstrual symptoms may have been the consequence of differing definitions in different studies. The final answer on this possible association may result from using a clear definition of premenstrual symptoms based on emotional difficulties and a well defined research oriented criteria for the diagnoses of affective disorder.
对105名大学新生进行了前瞻性研究，以探讨基于情绪症状的经前综合征与原发性情感障碍之间的相关性。有经前症状的学生出现严重抑郁发作史的可能性是对照组的两倍，有抑郁症近亲的可能性也是对照组的两倍。有经前情绪症状的女性中有7%在随后一年出现情感发作，而对照组中无人出现。经前综合征并未影响学业成绩，也与职业抱负的降低无关。过去关于抑郁症与经前症状关系的研究结果不一致，可能是由于不同研究中的定义不同所致。关于这种可能关联的最终答案可能来自基于情绪困扰对经前症状进行明确界定，以及采用针对情感障碍诊断的明确的研究导向标准。
