PiS和PiZα1抗胰蛋白酶多态性与职业性接触石棉时患石棉肺的风险

PiS and PiZ alpha 1 antitrypsin polymorphism and the risk for asbestosis in occupational exposure to asbestos.

作者信息

Lafuente M J, Casterad X, Laso N, Mas S, Panades R, Calleja A, Hernandez S, Turuguet D, Ballesta A, Ascaso C, Lafuente A

机构信息

Department of Pharmacology, School of Medicine, IDIBAPS, Casanova 143, University of Barcelona, 08036 Barcelona, Spain.

出版信息

Toxicol Lett. 2002 Nov 15;136(1):9-17. doi: 10.1016/s0378-4274(02)00283-7.

DOI:10.1016/s0378-4274(02)00283-7

PMID:12368052

Abstract

Alpha 1 antitrypsin is a highly polymorphic anti-elastase enzyme, especially active in the protection of alveoli and liver. Here we studied the distribution of two deficient alleles PiZ and Pi S, in 194 asbestos workers, of whom 100 were asbestosis cases, and 94 were controls without disease (exposed controls, EC). A second group of controls without asbestos exposure (non-exposed controls, NEC; n=122) was also included. Multivariate analysis adjusted by age and smoking habit showed ninefold risk for asbestosis in PiZ heterozygous individuals and 5.9-fold risk for PiS homozygous although differences were only significant in the first case (cases vs. EC: OR 8.9; p=0.04). Considering both genotypes (PiZ heterozygous, PiS homozygous) we obtained an OR of 8 (p=0.01). Our results suggest that the alpha 1 antitrypsin polymorphisms, especially PiZ, could help to predict asbestosis risk and confirm the high prevalence of the PiS allele in Spain.

摘要

α1抗胰蛋白酶是一种高度多态性的抗弹性蛋白酶，在保护肺泡和肝脏方面具有特别的活性。在此，我们研究了194名石棉工人中两种缺陷等位基因PiZ和PiS的分布情况，其中100人患有石棉肺，94人作为无疾病的对照（暴露对照，EC）。还纳入了第二组无石棉暴露的对照（非暴露对照，NEC；n = 122）。经年龄和吸烟习惯调整的多变量分析显示，PiZ杂合个体患石棉肺的风险增加9倍，PiS纯合个体患石棉肺的风险增加5.9倍，尽管仅在第一种情况中差异具有统计学意义（病例组与EC组：OR 8.9；p = 0.04）。综合考虑两种基因型（PiZ杂合、PiS纯合），我们得出的OR为8（p = 0.01）。我们的结果表明，α1抗胰蛋白酶多态性，尤其是PiZ，可能有助于预测石棉肺风险，并证实PiS等位基因在西班牙的高流行率。