Afanas'eva I S, Spitsyn V A, Tsurikova G V
Genetika. 1993 Oct;29(10):1727-32.
The polymorphism and serum levels of alpha 1-antitrypsin (AT) were studied in asbestosis patients, the control and the workers exposed to mineral flax longer or less than ten years. M1S, M3S, M1Z and M2M2 phenotypes had low concentration of this protein. In the course of contact with mineral flax decrease in alpha 1-AT concentration was found. The phenotypes with low protein levels were very rare among workers contacting with asbestos for a long time, and one of them--M1S was more often encountered in asbestosis patients. The standard deviation from the alpha 1-AT concentration was significantly higher in asbestosis patients.
对石棉沉着病患者、对照组以及接触矿棉时间长于或短于十年的工人的α1 -抗胰蛋白酶（AT）的多态性和血清水平进行了研究。M1S、M3S、M1Z和M2M2表型的这种蛋白质浓度较低。在接触矿棉的过程中，发现α1 - AT浓度降低。蛋白质水平低的表型在长期接触石棉的工人中非常罕见，其中一种——M1S在石棉沉着病患者中更常出现。石棉沉着病患者α1 - AT浓度的标准差显著更高。
