Kofoed Steen Christian, Grønholdt Marie-Louise Moes, Bismuth Jean, Wilhjelm Jens E, Sillesen Henrik, Nordestgaard Børge G
Department of Vascular Surgery, Gentofte University Hospital, Copenhagen, Denmark.
J Vasc Surg. 2002 Oct;36(4):783-92.
We tested whether fasting and postprandial triglyceride-rich lipoprotein elevations are gender specific (1) in patients with carotid artery stenosis >or=50% vs controls, and (2) in patients with echolucent, rupture-prone plaques compared with controls.
We studied 66 controls and 323 patients with carotid artery stenosis >or=50%, of which 160 had echolucent plaques. Participants underwent a fat-tolerance test and carotid artery plaque evaluation with use of high-resolution B-mode ultrasound and computerized image analysis. By comparison, female cases with carotid stenosis >or=50% had higher fasting and postprandial triglyceride levels than did controls; however, this difference was not observed between male cases and controls. Fasting and postprandial very-low-density lipoprotein (VLDL) and intermediate density liprotein (IDL) cholesterol levels were elevated; low density lipoprotein (LDL) cholesterol level was unchanged, and high density lipoprotein (HDL) cholesterol level was reduced in both female and male cases vs controls. Fasting and postprandial triglyceride levels were elevated in women with echolucent plaques vs controls, but not in women with echo-rich plaques, or in men with echolucent or echo-rich plaques. Fasting and postprandial VLDL and IDL cholesterol levels were elevated, LDL cholesterol level was unchanged, and HDL cholesterol level was reduced in both female and male patients with echolucent plaques vs controls.
Fasting and postprandial triglyceride-rich lipoproteins (but not LDLs) are elevated in patients with carotid artery stenosis of >or=50% compared with controls, and particularly identify echolucent, rupture-prone carotid plaques. These observations are more pronounced in women than in men.
我们测试了（1）在颈动脉狭窄≥50%的患者与对照组中，以及（2）在具有无回声、易破裂斑块的患者与对照组中，空腹和餐后富含甘油三酯的脂蛋白升高是否存在性别差异。
我们研究了66名对照组和323名颈动脉狭窄≥50%的患者，其中160名有无回声斑块。参与者接受了脂肪耐量测试，并使用高分辨率B型超声和计算机图像分析进行颈动脉斑块评估。相比之下，颈动脉狭窄≥50%的女性患者空腹和餐后甘油三酯水平高于对照组；然而，男性患者与对照组之间未观察到这种差异。空腹和餐后极低密度脂蛋白（VLDL）和中间密度脂蛋白（IDL）胆固醇水平升高；低密度脂蛋白（LDL）胆固醇水平未改变，高密度脂蛋白（HDL）胆固醇水平在女性和男性患者与对照组相比均降低。有无回声斑块的女性空腹和餐后甘油三酯水平高于对照组，但有回声丰富斑块的女性或有无回声或回声丰富斑块的男性则不然。有无回声斑块的女性和男性患者空腹和餐后VLDL和IDL胆固醇水平升高，LDL胆固醇水平未改变，HDL胆固醇水平降低。
与对照组相比，颈动脉狭窄≥50%的患者空腹和餐后富含甘油三酯的脂蛋白（而非LDL）升高，尤其可识别无回声、易破裂的颈动脉斑块。这些观察结果在女性中比在男性中更明显。
