Tiker Filiz, Gürakan Berkan, Tarcan Aylin
Department of Pediatrics, Faculty of Medicine, Baskent University, Adana, Turkey.
Ann Trop Paediatr. 2002 Sep;22(3):225-8. doi: 10.1179/027249302125001606.
This study investigated bilirubin levels in 282 1-month-old, healthy, term infants from the Adana region in southern Turkey. Total bilirubin was > 5 mg/dl in 20.2% of the infants and > 10 mg/dl in 6% of the group. Thyroid function and levels of alanine aminotransferase, aspartate aminotransferase and glucose-6-phosphate dehydrogenase were determined in babies with bilirubin levels > 5 mg/dl. The results were normal in all but one case, an infant with a bilirubin level of > 10 mg/dl and glucose-6-phosphate dehydrogenase deficiency. The results indicate that in this population a 5-mg/dl cut-off level for further investigation would mean that 20% of all infants would require further evaluation. This is not cost-effective. Based on our findings, we suggest that the cut-off level for investigating prolonged jaundice in term, 1-month-old, healthy infants in the Turkish population should be > 5 mg/dl.
本研究调查了来自土耳其南部阿达纳地区的282名1月龄健康足月儿的胆红素水平。20.2%的婴儿总胆红素>5mg/dl，该组中有6%的婴儿总胆红素>10mg/dl。对胆红素水平>5mg/dl的婴儿测定了甲状腺功能以及丙氨酸转氨酶、天冬氨酸转氨酶和葡萄糖-6-磷酸脱氢酶的水平。除1例胆红素水平>10mg/dl且患有葡萄糖-6-磷酸脱氢酶缺乏症的婴儿外，其他所有婴儿的检查结果均正常。结果表明，在该人群中，将5mg/dl作为进一步检查的临界值意味着所有婴儿中有20%需要进一步评估。这并不具有成本效益。基于我们的研究结果，我们建议，对于土耳其人群中1月龄健康足月儿的持续性黄疸进行检查的临界值应>5mg/dl。
