Courtright Paul, Fine David, Broadhead Robin L, Misoya Lincy, Vagh Mustali
Department of Ophthalmology, University of British Columbia, Vancouver, Canada.
Ann Trop Paediatr. 2002 Sep;22(3):239-43. doi: 10.1179/027249302125001615.
We investigated the relationship between abnormal vitamin A cytology and mortality in infants less than 9 months of age with measles. In a 12-month period, 116 children of this age with measles consecutively admitted to Queen Elizabeth Central Hospital (QECH) in Blantyre, Malawi were enrolled in the study. All guardians of patients were interviewed and clinical information and consent were obtained in a standardised fashion. Conjunctival impression cytology (CIC) was attempted on all and collected from 93 (80%) children. The overall mortality was 16%. The proportional hazards model revealed that the presence of pneumonia on admission (hazard ratio 9.58, p = 0.0002) and an abnormal vitamin A CIC on admission (hazard ratio 6.40, p = 0.003) were independently associated with mortality. Our findings suggest a relationship between abnormal vitamin A CIC and fatality in infants under 9 months of age.
我们研究了9个月以下患麻疹婴儿的维生素A细胞学异常与死亡率之间的关系。在12个月期间，连续入住马拉维布兰太尔伊丽莎白女王中央医院（QECH）的116名这个年龄段的患麻疹儿童被纳入研究。对所有患者的监护人进行了访谈，并以标准化方式获取了临床信息和同意书。对所有儿童都尝试进行了结膜印迹细胞学检查（CIC），并从93名（80%）儿童中采集到了样本。总死亡率为16%。比例风险模型显示，入院时存在肺炎（风险比9.58，p = 0.0002）和入院时维生素A CIC异常（风险比6.40，p = 0.003）与死亡率独立相关。我们的研究结果表明，9个月以下婴儿维生素A CIC异常与死亡之间存在关联。
